2012
DOI: 10.1371/journal.pone.0048967
|View full text |Cite
|
Sign up to set email alerts
|

DlgS97/SAP97, a Neuronal Isoform of Discs Large, Regulates Ethanol Tolerance

Abstract: From a genetic screen for Drosophila melanogaster mutants with altered ethanol tolerance, we identified intolerant (intol), a novel allele of discs large 1 (dlg1). Dlg1 encodes Discs Large 1, a MAGUK (Membrane Associated Guanylate Kinase) family member that is the highly conserved homolog of mammalian PSD-95 and SAP97. The intol mutation disrupted specifically the expression of DlgS97, a SAP97 homolog, and one of two major protein isoforms encoded by dlg1 via alternative splicing. Expression of the major isofo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
38
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 21 publications
(38 citation statements)
references
References 65 publications
(117 reference statements)
0
38
0
Order By: Relevance
“…Corl et al (2009) had previously screened 850 pGal4 insertion lines for changes in ethanol sensitivity. From this collection, Maiya et al (2012) selected 42 lines to assay for their ability to acquire ethanol tolerance. They identified a gene called discs large 1 (dlg1).…”
Section: Learning and Memorymentioning
confidence: 99%
“…Corl et al (2009) had previously screened 850 pGal4 insertion lines for changes in ethanol sensitivity. From this collection, Maiya et al (2012) selected 42 lines to assay for their ability to acquire ethanol tolerance. They identified a gene called discs large 1 (dlg1).…”
Section: Learning and Memorymentioning
confidence: 99%
“…Interestingly, DlgS97 was found to associate with a known alcohol target, the NMDA receptor (NMDAR; Ron, 2004;Ron & Wang, 2009, chap. 4), and reduced levels of the NR1 subunit of the NMDA receptor in flies also attenuated the development of rapid tolerance to the sedative effects of alcohol (Maiya et al, 2012). Importantly, conditional deletion of the mammalian homolog of DlgS97, SAP97, in mice blocked the acute tolerance to the hypnotic actions of alcohol (Maiya et al, 2012).…”
Section: Acute Alcohol-induced Sedation and Rapid Tolerancementioning
confidence: 96%
“…4), and reduced levels of the NR1 subunit of the NMDA receptor in flies also attenuated the development of rapid tolerance to the sedative effects of alcohol (Maiya et al, 2012). Importantly, conditional deletion of the mammalian homolog of DlgS97, SAP97, in mice blocked the acute tolerance to the hypnotic actions of alcohol (Maiya et al, 2012). Interestingly, PSD-95 KO mice exhibit greater signs of alcohol intoxication and reduced levels of alcohol intake as compared to WT littermates (Camp et al, 2011).…”
Section: Acute Alcohol-induced Sedation and Rapid Tolerancementioning
confidence: 96%
See 2 more Smart Citations