“…As a recent example, Heberlein and colleagues identified the D. melanogaster gene discs large 1 (Dlg1), whose two splice isoforms, DlgA and DlgS97, encode homologs of the mammalian neuronal scaffolding proteins PSD95 and SAP97, respectively, were culled from a genetic screen aimed at identifying mutants with altered acute tolerance to alcohol (Maiya et al, 2012). The specific disruption of the DlgS97 splice variant, but not DlgA, in fruit flies blocked the development of acute tolerance to alcohol, as assessed using the inebriometer apparatus (Maiya et al, 2012). Interestingly, DlgS97 was found to associate with a known alcohol target, the NMDA receptor (NMDAR; Ron, 2004;Ron & Wang, 2009, chap.…”