DLX6-AS1: An Indispensable Cancer-related Long Non-coding RNA

Hu, Chengyu; Li, Kai; Wang, Bei; Xu, Wen; Lin, Yexiang; Yuan, Chengfu

doi:10.2174/1381612826666201029100151

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…This lncRNA plays a crucial role in a range of biological processes, such as regulating tumour proliferation, migration and invasion. 179 Tumour‐derived exosomes can be ingested by macrophages in the tumour microenvironment and eventually promote tumour progression and metastasis. 180 There are some reports on the functions of HCC‐derived exosomes in human cancers.…”

Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

“…DLX6‐AS1 has been demonstrated to function in tumours by ceRNA for binding to and inhibiting the function of miRNAs. This lncRNA plays a crucial role in a range of biological processes, such as regulating tumour proliferation, migration and invasion 179 . Tumour‐derived exosomes can be ingested by macrophages in the tumour microenvironment and eventually promote tumour progression and metastasis 180 .…”

Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

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Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC), as the most prevalent liver malignancy, is annually diagnosed in more than half a million people worldwide. HCC is strongly associated with hepatitis B and C viral infections as well as alcohol abuse. Obesity and nonalcoholic fatty liver disease (NAFLD) also significantly enhance the risk of liver cancer. Despite recent improvements in therapeutic approaches, patients diagnosed in advanced stages show poor prognosis. Accumulating evidence provides support for the regulatory role of non‐coding RNAs (ncRNAs) in cancer. There are a variety of reports indicating the regulatory role of microRNAs (miRNAs) in different stages of HCC. Long non‐coding RNAs (LncRNAs) exert their effects by sponging miRNAs and controlling the expression of miRNA‐targeted genes. Circular RNAs (circRNAs) perform their biological functions by acting as transcriptional regulators, miRNA sponges and protein templates. Diverse studies have illustrated that dysregulation of competing endogenous RNA networks (ceRNETs) is remarkably correlated with HCC‐causing diseases such as chronic viral infections, nonalcoholic steatohepatitis and liver fibrosis/cirrhosis. The aim of the current article was to provide an overview of the role and molecular mechanisms underlying the function of ceRNETs that modulate the characteristics of HCC such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis and metastasis. The current knowledge highlights the potential of these regulatory RNA molecules as novel diagnostic biomarkers and therapeutic targets in HCC.

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Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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“…LncRNAs are composed of at least 200 nucleotides, are easily detectable in human body fluids, and their binding and expression are highly specific. Several recent studies have shown that the differential expression of lncRNAs is related to PCa [ 139 , 140 , 141 ]. Throughout this topic, cell-free lncRNAs with potential application in the diagnosis and prognosis of this malignant disease will be discussed and summarized in Table 2 .…”

Section: Pancreatic Cancer Diagnosis and Prognosis By Cell-free Rnasmentioning

confidence: 99%

Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer

et al. 2023

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A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage. This highlights the urgent need to identify biomarkers that can be used for the early detection, staging, treatment monitoring, and prognosis of PCa. A novel approach called liquid biopsy has emerged in recent years, which is a less- or non-invasive procedure since it focuses on plasmatic biomarkers such as DNA and RNA. In the blood of patients with cancer, circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) have been identified such as DNA, mRNA, and non-coding RNA (miRNA and lncRNA). The presence of these molecules encouraged researchers to investigate their potential as biomarkers. In this article, we focused on circulating cfNAs as plasmatic biomarkers of PCa and analyzed their advantages compared to traditional biopsy methods.

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“…In osteosarcoma, lncRNAs distal-less homeobox 6 antisense 1 (DLX6-AS1) was highly expressed in osteosarcoma tissue and cell lines [ 123 , 127 , 128 ]. Moreover, its expression was significantly correlated with advanced TNM stage, tumor grade, distant metastasis and poor prognosis [ 123 , 127 ].…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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DLX6-AS1: An Indispensable Cancer-related Long Non-coding RNA

Cited by 11 publications

References 35 publications

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

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