DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
Bingchen Lv,
Ping Fu,
Miao Wang
et al.
Abstract:ObjectiveNeuronal precursor cells expressed developmentally down‐regulated 4 (Nedd4) are believed to play a critical role in promoting the degradation of substrate proteins and are involved in numerous biological processes. However, the role of Nedd4 in intracerebral hemorrhage (ICH) remains unknown. This study aims to investigate the regulatory role of Nedd4 in the ICH model.MethodsMale C57BL/6J mice were induced with ICH. Subsequently, the levels of glutathione peroxidase 4 (GPX4), malondialdehyde (MDA) conc… Show more
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