DNA and carbon nanotubes as medicine

Cheung, William; Pontoriero, Francesco; Taratula, Oleh; Chen, Alex M.; He, Huixin

doi:10.1016/j.addr.2010.03.007

Cited by 184 publications

(88 citation statements)

References 145 publications

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“…Another recent development in nanoparticle-mediated siR-NA delivery is the incorporation of carbon nanotubes (CNTs) (Lacerda et al, 2006;Cheung et al, 2010) into the polymeric composite system due to chemical inertness, easy surface functionalization, and unique structure of CNTs. Inherent hydrophobicity of pristine CNT necessitates functionalization of CNT to impart water solubility and biocompatibility.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Polymers in Small-Interfering RNA Delivery

Singha

Namgung

Kim

2011

Nucleic Acid Therapeutics

185

112

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This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.

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Section: Carbon Nanotubesmentioning

confidence: 99%

Polymers in Small-Interfering RNA Delivery

Singha

Namgung

Kim

2011

Nucleic Acid Therapeutics

185

112

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“…111 It was further found that DNA-CNTs could penetrate lymphocytes instantaneously with a needle-like mechanism, thus reducing cytotoxic effects. 112 fCNTs were found to be similar to cellpenetrating proteins, as they can penetrate cells without endocytosis; 47 however, the internalization of nanomaterials depends on the type of functionalization process.…”

Section: Functionalization Using Proteinmentioning

confidence: 99%

Functionalized carbon nanotubes: biomedical applications

Vardharajula¹,

Ali²,

Tiwari³

et al. 2012

IJN

184

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Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in muchreduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.

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“…They are highly stable and versatile in terms of their structural conformation, charge, strength, flexibility, etc. (Cheung, et al, 2010). This material can also be functionalized with drugs and/or biomolecules for diagnostic and therapeutic purposes.…”

Section: Carbon Nanostructures Metal Particles and Quantum Dotsmentioning

confidence: 99%

“…Nanotechnology has opened new possibilities for ex vivo detection methods (e.g., applicable to mutation screening) as well as biomarkers of disease, with several technologies being also applicable for in vivo imaging (Cai, et al, 2003, Corstjens, et al, 2005, Bailey, et al, 2009, Cheung, et al, 2010, Choi & Frangioni, 2010. These strategies are considerably more sensitive than traditional methods, permitting detection in smaller samples and/or providing more accurate measurements and tracings of the parameters of interest.…”

Section: Nanomedicine Applications For Treatment Of Genetic Diseasesmentioning

confidence: 99%