DNA Attachment and Hybridization at the Silicon (100) Surface

Zhang, Lin; Strother, Todd; Cai, Wei; Cao, Xiao‐Ping; Smith, Lloyd M.; Hamers, Robert J.

doi:10.1021/la010892w

Cited by 217 publications

(238 citation statements)

References 21 publications

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“…On nonoxidized silicon surfaces, however, protection and deprotection of the amine group is required. 139 The great majority of these SAM-forming molecules are commercially available, so that SAM deposition procedures involve no, or minimal, synthetic effort. 140 Linking of biomolecules onto amino-termini can be accomplished in a three-step procedure using heterobifunctional reagents (e.g.…”

Section: Maleimide-derivatized Surfacesmentioning

confidence: 99%

The molecular level modification of surfaces: from self-assembled monolayers to complex molecular assemblies

2011

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The modification of surfaces with self-assembled monolayers (SAMs) containing multiple different molecules, or containing molecules with multiple different functional components, or both, has become increasingly popular over the last two decades. This explosion of interest is primarily related to the ability to control the modification of interfaces with something approaching molecular level control and to the ability to characterise the molecular constructs by which the surface is modified. Over this time the level of sophistication of molecular constructs, and the level of knowledge related to how to fabricate molecular constructs on surfaces have advanced enormously. This critical review aims to guide researchers interested in modifying surfaces with a high degree of control to the use of organic layers. Highlighted are some of the issues to consider when working with SAMs, as well as some of the lessons learnt (169 references). 2011 The Royal Society of Chemistry. The modification of surfaces with self-assembled monolayers (SAMs) containing multiple different molecules, or containing molecules with multiple different functional components, or both, has become increasingly popular over the last two decades. This explosion of interest is primarily related to the ability to control the modification of interfaces with something approaching molecular level control and to the ability to characterise the molecular constructs by which the surface is modified. Over this time the level of sophistication of molecular constructs, and the level of knowledge related to how to fabricate molecular constructs on surfaces have advanced enormously. This critical review aims to guide researchers interested in modifying surfaces with a high degree of control to the use of organic layers. Highlighted are some of the issues to consider when working with SAMs, as well as some of the lessons learnt (169 references).

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Section: Maleimide-derivatized Surfacesmentioning

confidence: 99%

The molecular level modification of surfaces: from self-assembled monolayers to complex molecular assemblies

2011

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“…This situation has two ways out: In the first route, one attaches a precursor to the surface that can stand such harsh conditions, which is subsequently transformed into the bioactive monolayer. Such an approach has been taken by, for example, Hamers and co-workers, [10,11] and in the elegant DNA attachment studies of Horrocks, Houlton and coworkers. [11,13] The second route would make use of mild reaction conditions that are, in principle, compatible with such bioactive moieties.…”

mentioning

confidence: 96%

“…Such an approach has been taken by, for example, Hamers and co-workers, [10,11] and in the elegant DNA attachment studies of Horrocks, Houlton and coworkers. [11,13] The second route would make use of mild reaction conditions that are, in principle, compatible with such bioactive moieties. In the case of porous silicon, such an approach has been taken by Buriak and Stewart through either the use of a white-light-promoted reaction [14] or a hydride-abstracting agent.…”

mentioning

confidence: 96%

Covalently Attached Monolayers on Hydrogen‐Terminated Si(100): Extremely Mild Attachment by Visible Light

et al. 2004

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“…[1][2][3][4][5] Although many organic reactions on the Si(100)-2×1 surface have been examined, fewer have been explored on the Ge(100)-2×1 surface. Furthermore, although the set organic functional groups whose reactivity has been explored on semiconductor surfaces is now quite extensive, many organic functional groups are yet to be examined.…”

Section: Introductionmentioning

confidence: 99%

Attachment of Alanine and Arginine to the Ge(100)-2×1 Surface

2007

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The reactions of the amino acids alanine and arginine on the Ge(100)-2×1 surface are investigated using density functional theory. Arginine presents a unique reactivity not previously explored on semiconductor surfaces. Arginine dative bonds to the surface dimer through its imine lone pair, resulting in two adsorbed conformations with adsorption energies of 30.7 and 33.8 kcal/mol, significantly stronger than amine dative bonds on Ge(100)-2×1. We predict a N-H dissociation and an ene reaction pathway from each of these two conformers with the ene reactions kinetically favored over N-H dissociation of the imine N-H bond and the ene reaction from the cis state favored both kinetically and thermodynamically over the trans ene reaction. Our results for the reactions of the hydroxyl, carbonyl, and amine functional groups are similar to previous observations for analogous reactions of small organic molecules on Ge(100)-2×1. We find that O-H dissociation from the carbonyl dative bonded state is the most favorable pathway. The amine dative bonded state is slightly more stable than the carbonyl dative bonded state. We find that [2+2] cycloaddition through the CdN double bond is exothermic by only 3.3 kcal/mol.

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DNA Attachment and Hybridization at the Silicon (100) Surface

Cited by 217 publications

References 21 publications

The molecular level modification of surfaces: from self-assembled monolayers to complex molecular assemblies

The molecular level modification of surfaces: from self-assembled monolayers to complex molecular assemblies

Covalently Attached Monolayers on Hydrogen‐Terminated Si(100): Extremely Mild Attachment by Visible Light

Attachment of Alanine and Arginine to the Ge(100)-2×1 Surface

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