As the Internet of Things (IoT) permeates our lives, connecting everything from household appliances to complex industrial systems, the imperative to secure these devices intensifies. Cryptography, as a cornerstone of digital security, plays a crucial role in safeguarding transmission channels from intrusions and misuse. Cryptography secures communications and data within IoT networks by ensuring three key functions: confidentiality, integrity, and authentication. DNA-based cryptography emerges as a promising innovation in the field of cybersecurity, particularly for the Internet of Things (IoT), where data and communication security is an escalating concern. Utilizing the unique properties of DNA, such as its massive storage capacity and biomolecular complexity, this approach introduces a novel dimension of security. This study introduces a balanced approach within DNA cryptography to enhance message security in Internet of Things (IoT) settings. It outlines a method for creating secure symmetric keys using DNA sequences, typically derived from human chromosomes, and then applies biological techniques like transcription and a biological Xor operation. This step is succeeded by a translation phase that utilizes an index table created from an initial key, making the process more complex.