2019
DOI: 10.1021/acssensors.9b00209
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DNA-Based Photoacoustic Nanosensor for Interferon Gamma Detection

Abstract: Tracking protein levels in the body is vital in both research and medicine, where understanding their physiological roles provides insight into their regulation in homeostasis and diseases. In medicine, protein levels are actively sampled since they continuously fluctuate, reflecting the status of biological systems and provide insight into patient health. One such protein is interferon gamma, a clinically relevant protein with immunoregulatory functions that play critical roles against infection. New tools fo… Show more

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Cited by 25 publications
(23 citation statements)
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“…Recently, Morales et al developed a DNA-based PA nanosensor to detect interferon-gamma (IFNγ) that plays a critical role in activating immunity against infections. 124 In the presence of IFNγ, the DNA structure's arms were folded to induce stacking of Pc dye, achieving a 55% increase in PA signal [ Fig. 5(c) ].…”
Section: Biomedical Applications Of P C /N Csmentioning
confidence: 99%
“…Recently, Morales et al developed a DNA-based PA nanosensor to detect interferon-gamma (IFNγ) that plays a critical role in activating immunity against infections. 124 In the presence of IFNγ, the DNA structure's arms were folded to induce stacking of Pc dye, achieving a 55% increase in PA signal [ Fig. 5(c) ].…”
Section: Biomedical Applications Of P C /N Csmentioning
confidence: 99%
“…Most of the recent class of fluorescence guided surgery molecular contrast agents for cancer are NIR, 14 , 41 some of which may ultimately be used as a contrast agent for DiFC. Likewise, circulating fluorescent sensors 7 , 42 can be engineered to emit light in NIR wavelengths.…”
Section: Discussionmentioning
confidence: 99%
“…Most of the recent class of fluorescence guided surgery molecular contrast agents for cancer are NIR 13,38 , some of which may ultimately be used as a contrast agent for DiFC. Likewise, circulating fluorescent sensors 7,39 can be engineered to emit light in NIR wavelengths.…”
Section: Discussionmentioning
confidence: 99%