DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders

Muhamadejev, Ruslan; Živković, Lada; Dzintare, Maija; Sjakste, Nikolajs

doi:10.1016/j.cbi.2021.109638

Cited by 4 publications

(1 citation statement)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the possible genotoxic effects of chemical compounds used as medical remedies are intensively studied. There is a vast body of literature concerning both natural and synthetic compounds [ 28 , 29 ]. Much less attention is paid to the genotoxic effects of animal venoms and other compounds of animal origin, although animal venoms per se are in the focus of interest of numerous researchers [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin

Sjakste

Gajski

2023

Toxins

Self Cite

View full text Add to dashboard Cite

Envenomation by animal venoms remains a serious medical and social problem, especially in tropical countries. On the other hand, animal venoms are widely used as a source of biologically active compounds for the development of novel drugs. Numerous derivatives of animal venoms are already used in clinical practice. When analysing the mechanisms of action of animal venoms, attention is usually focused on the main target of the venom’s enzymes and peptides such as neurotoxic, cytotoxic or haemorrhagic effects. In the present review, we would like to draw attention to the “hidden” effects of animal venoms and their derivatives in regard to DNA damage and/or protection against DNA damage. Alkaloids and terpenoids isolated from sponges such as avarol, ingenamine G or variolin B manifest the capability to bind DNA in vitro and produce DNA breaks. Trabectidin, isolated from a sea squirt, also binds and damages DNA. A similar action is possible for peptides isolated from bee and wasp venoms such as mastoparan, melectin and melittin. However, DNA lesions produced by the crude venoms of jellyfish, scorpions, spiders and snakes arise as a consequence of cell membrane damage and the subsequent oxidative stress, whereas certain animal venoms or their components produce a genoprotective effect. Current research data point to the possibility of using animal venoms and their components in the development of various potential therapeutic agents; however, before their possible clinical use the route of injection, molecular target, mechanism of action, exact dosage, possible side effects and other fundamental parameters should be further investigated.

show abstract

Section: Introductionmentioning

confidence: 99%