DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes

Abstract

The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO3 (Oct-dtc = Octyldithiocarbamate and bpy = 2,2′ -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO3, have been synthesized and characterized by elemental analyses, molar conductivity measurements, IR, 1H NMR, and electronic spectra studies. Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out. They show Ic50 values lower than that of cisplatin. The complexes have been investigated for their interaction with calf thymus DNA (CT-DNA) by utilizing the electronic absorption spectroscopy, fluorescence spectra, and ethidium bromide displacement and gel filtration techniques. Both of these water-soluble complexes bound cooperatively and intercalatively to the CT-DNA at very low concentrations. Several binding and thermodynamic parameters are also described.

Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy

“…and cancer (6). To achieve better biological activity, many studies of structural modification on compounds have been conducted (7)(8)(9)(10)(11), some of which were found to have excellent antitumor activity in vitro and in vivo. Due to many metal complexes exhibiting significant antiproliferative activity in clinic, many metal complexes of dithiocarbamates have been prepared and investigated in antitumor activity.…”

Copper Ion Attenuated the Antiproliferative Activity of Di-2-pyridylhydrazone Dithiocarbamate Derivative; However, There Was a Lack of Correlation between ROS Generation and Antiproliferative Activity

“…This aroused an interest to explore their potent applications both as anticancer agents and for treatment of many other disease conditions [10,11,12,13]. Owing to their versatile biological activities, many novel dithiocarbamate derivatives have been synthesized and their anticancer activities have been evaluated [14,15,16,17,18]. Moreover, many metal complexes, such as cisplatin, exhibited a significant antiproliferative activity, and it is known that dithiocarbamates exhibit a marked affinity to metal ions, especially transition metals.…”

Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines

“…Previously, three Pd(II) complexes of M(2,2′-bipyridine) (morpholine dithiocarbamate) NO 3 Pd(II) complexes, 1,10-phenanthroline hexyl dithiocarbamatopalladium (II) nitrate [32], and α -diimine platinum(II) and Pd(II) dithiocarbamate complexes [31] have been synthesized and characterized by good anticancer activity. However, dithiocarbamate complexes of metals could be more interesting and they display cytotoxic properties [30].…”