2006
DOI: 10.1016/j.jinorgbio.2006.06.001
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DNA Binding and cleavage activity of Ni(II) complex with all-trans retinoic acid

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Cited by 129 publications
(48 citation statements)
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References 16 publications
(22 reference statements)
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“…DNA is the primary intracellular target of anticancer reagents because interaction between metal complexes and DNA can cause damage in cancer cells, blocking cell division [1,2]. To date, much attention has been paid to binding of metal complexes containing multidentate aromatic ligands.…”
Section: Introductionmentioning
confidence: 99%
“…DNA is the primary intracellular target of anticancer reagents because interaction between metal complexes and DNA can cause damage in cancer cells, blocking cell division [1,2]. To date, much attention has been paid to binding of metal complexes containing multidentate aromatic ligands.…”
Section: Introductionmentioning
confidence: 99%
“…As discussed elsewhere, 36 cell viability is an important factor to evaluate the activity of a nanosystem by detecting the ability of cells to transform MTT to a purple formazan dye. 37,38 Different cells (2×10 4 cells/mL) were incubated in 96-well plates and cultivated, then different concentrations of Tf-NGO@Pt were added at different times.…”
Section: Mtt Assaymentioning
confidence: 99%
“…Yet it is noticed that the DNA-binding investigation of such complexes have been done relatively few. Because the interaction between metal complexes and DNA is in close relationship with their potential biological and pharmaceutical activities, 5,6) studies on DNA-binding of metal complexes are very important in the development of new therapeutic reagents and DNA molecular probes. In order to find more effective and less toxic anti-diabetic drugs, thousands of analogues of sulfonlyureas were synthesized.…”
mentioning
confidence: 99%
“…In order to find more effective and less toxic anti-diabetic drugs, thousands of analogues of sulfonlyureas were synthesized. 6,7) Here, we synthesized 1-cyclohexyl-3-tosylurea (H 2 L) and its two lanthanide(III) complexes. In addition DNA-binding property of two lanthanide(III) complexes with 1-cyclohexyl-3-tosylurea is reported in this paper.…”
mentioning
confidence: 99%
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