DNA binding and oxidative cleavage activity of ternary (l-proline)copper(II) complexes of heterocyclic bases

Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of l-ornithine copper (II) complexes

“…1). The electronic spectra of the complexes are in good agreement with the previously reported square pyramidal geometry of the complexes [36,37]. The complexes show a metal centered quasi-reversible …”

“…The strong binding affinity of the copper bis phen complex and the redox behavior of the copper center play an important role in inducing oxidative DNA cleavage. Chakravarty and co-workers recently explored amino acid transition metal based chemistry towards cleavage of DNA under physiological conditions by oxidative as well as photochemical means on charge transfer or d-d band excitation [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. The copper complex of L-lysine structure is closely resembles the copper-ornithine structure, which shows efficient chemical nuclease activity [25].…”

New ternary copper(II) complexes of l-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity

“…Designing and synthesis of bio-essential amino acid based transition metal complexes which are capable of cleaving DNA attracted much attention in the very recent time [30][31][32][33][34][35][36]. We have also previously reported chemical nuclease activity of proline/leucine/isoleucine based copper(II) complexes under physiological condition [37,38].…”

Aqua(1,10-phenanthroline-κ2N,N′)(DL-threoninato-κ2N,O1)copper(II) chloride dihydrate

“…For background to the interactions of transition-metal complexes with DNA, see: Vaidyanathan & Nair (2003); Rao et al (2007Rao et al ( , 2008 ;Kumar & Arunachalam (2007); Patel et al (2006); Wang et al (2007); Zhang et al (2004). For a related structure, see: Lu et al (2004).…”

“…Among all the transition metals, copper is the most widely used metals in these studies as it is a bioessential element with +1 and +2 oxidation states (Patel et al, 2006;Wang et al, 2007;Vaidyanathan et al, 2003 (Kumar et al, 2007;Zhang et al, 2004;Rao et al, 2007). In the title compound, aqua(DL-threoninato-κ 2 N,O) (1,10-phenanthroline)copper (II) chloride dihydrate, DL-threonine has been selected as the ligand for the complex.…”