2009
DOI: 10.1039/b809873p
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DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

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Cited by 162 publications
(143 citation statements)
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“…The therapeutic functions of many anticancer and antibacterial drugs stem from their noncovalent interaction with DNA substrates, including DNA duplexes and DNA quadruplexes (1)(2)(3)(4)(5)(6). The growing interest in the development and characterization of DNA-interactive agents has amplified the need for sensitive and versatile analytical techniques that are capable of characterizing the binding modes, sequence selectivities, and binding affinities of these compounds, as well as the structures of the resulting DNA/ligand complexes (7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…The therapeutic functions of many anticancer and antibacterial drugs stem from their noncovalent interaction with DNA substrates, including DNA duplexes and DNA quadruplexes (1)(2)(3)(4)(5)(6). The growing interest in the development and characterization of DNA-interactive agents has amplified the need for sensitive and versatile analytical techniques that are capable of characterizing the binding modes, sequence selectivities, and binding affinities of these compounds, as well as the structures of the resulting DNA/ligand complexes (7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…in the cavity of the junction). [14] A bisacridine bisintercalator that binds four-way junctions [15] was shown to also bind other DNA topologies. [16] The use of cylinder-bound 3WJs should add stability and rigidity to the DNA frame and enable the introduction of cylinder-linked functionality into DNA-based materials.…”
mentioning
confidence: 99%
“…A majority of chemotherapeutic anticancer agents currently used are DNA-binding drugs [5,6]. The binding of DNA to ligands results from stacking of aromatic rings, hydrogen bonding, electrostatic interaction, van der Waals interactions and structure compatibility.…”
Section: Introductionmentioning
confidence: 99%