DNA binding graphene quantum dots inhibit dual topoisomerases for cancer chemotherapy

Geng, Bijiang; Hu, Jinyan; Li, Ping; Pan, Dengyu; Shen, Longxiang

doi:10.1016/j.carbon.2021.11.028

Cited by 12 publications

(10 citation statements)

References 38 publications

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“…A broad distinct peak at approximately 22°can be detected in the X-ray diffraction (XRD) patterns (Supplementary Fig. 1), indicating a wider (002) layer spacing of these CDs 52 . The graphitic structure of the three kinds of CDs was confirmed by the Raman spectra (Supplementary Fig.…”

Section: Synthesis Of Cds With Different Acceptor/donator Modificationsmentioning

confidence: 99%

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Geng

et al. 2022

Nat Commun

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178

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Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation of e−–h+ pairs and fast transfer to reaction sites. Importantly, the cancer-specific targeting and high-level intratumor enrichment of the theranostic CDs are achieved by cancer cell membrane encapsulation for precision SDT with complete eradication of solid tumors by single injection and single irradiation. These results will open up a promising approach to engineer phosphorescent materials with long-lived triplet excited states for sonodynamic precision tumor therapy.

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Section: Synthesis Of Cds With Different Acceptor/donator Modificationsmentioning

confidence: 99%

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Geng

et al. 2022

Nat Commun

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178

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“…Compared with traditional dyes, semiconductor materials and even carbon-based QDs, CDs have more potential promising for in vivo tracing due to their relative safety. For example, graphene QDs exhibited obvious cytotoxicity at very low concentrations (IC50 = 1.5 µg/mL), which is not suitable for in vivo tracing 161 . The further understanding of its potential toxicity and related toxicity mechanism can better promote its clinical application.…”

Section: General Properties Of Lw-cds For In Vivo ...mentioning

confidence: 99%

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Li¹,

Huang²,

Yuan³

et al. 2023

Theranostics

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As a novel strategy for in vivo visualization tracking and monitoring, carbon dots (CDs) emitting long wavelengths (LW, 600-950 nm) have received tremendous attention due to their deep tissue penetration, low photon scattering, satisfactory contrast resolution and high signal-to-background ratios. Although, the mechanism of CDs emitting LW remains controversial and what properties are best for in vivo visualization have not been specifically elucidated, it is more conducive to the in vivo application of LW-CDs through rational design and ingenious synthesis based on the appreciation of the luminescence mechanism. Therefore, this review analyzes the current tracer technologies applied in vivo and their advantages and disadvantages, with emphasis on the physical mechanism of emitting LW fluorescence for in vivo imaging. Subsequently, the general properties and merits of LW-CDs for tracking and imaging are summarized. More importantly, the factors affecting the synthesis of LW-CDs and its luminescence mechanism are highlighted. Simultaneously, the application of LW-CDs for disease diagnosis, integration of diagnosis and therapy are summarized. Finally, the bottlenecks and possible future directions of LW-CDs in visualization tracking and imaging in vivo are detailly discussed.

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“…Carbon dots (CDs) have emerged as a promising category of luminescent materials, drawing increasing interest for applications in biological imaging, chemical sensors, biodetection, and electrochemiluminescence. − Their appeal lies in attributes such as good water solubility, low toxicity, and robust thermal and chemical stability. , Some recent strategies to enhance their performance involve incorporating CDs with exceptional luminescent properties into protective matrices such as inorganic salts, silica gel, polyurethane, and polystyrene. − These strategies are highly dependent on intermolecular interactions to effectively inhibit the nonradiative decay process of the triplet exciton, minimize oxygen-induced quenching, and facilitate efficient RTP emission …”

Section: Introductionmentioning

confidence: 99%

Composite Carbon Dot Materials with Long Room Temperature Phosphorescence in Solid and Liquid Environments for Encryption Technologies and Biological Detection

Gao,

Zhang,

Huang

et al. 2024

ACS Appl. Nano Mater.

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This study presents an innovative approach to design room temperature phosphorescent (RTP) carbon dot composites with ultralong afterglow lifetimes in both solid and liquid states. The proposed carbon dot composites, namely, L-NCDs-BA (solid) and L-NCDs-SiO2 (liquid), were synthesized through a straightforward hydrothermal method. The solid composite achieved an afterglow lifetime of 1.63 s, while the liquid composite demonstrated a notable afterglow of 1.30 s. These values surpass most reported nonmetallic RTP materials to date. Morphological and structural analyses confirmed effective encapsulation within a boric acid matrix and a silica framework, providing protection against quenching factors. The composites displayed excitation-dependent fluorescence emission, allowing for color-tunable fluorescence. Applications in information encryption and biological detection were explored, showcasing potential in anticounterfeiting and selective sensing of L-NCDs carbon dot composites. This study provides a comprehensive exploration of the structure, photophysical properties, and applications of ultralong-lived RTP carbon dot composites. The synthesized materials offer promising avenues for advanced optoelectronic devices, anticounterfeiting technologies, and selective biological detection systems.

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DNA binding graphene quantum dots inhibit dual topoisomerases for cancer chemotherapy

Cited by 12 publications

References 38 publications

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Composite Carbon Dot Materials with Long Room Temperature Phosphorescence in Solid and Liquid Environments for Encryption Technologies and Biological Detection

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