2020
DOI: 10.1101/2020.06.02.130492
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DNA binding reorganizes the intrinsically disordered C-terminal region of PSC inDrosophilaPRC1

Abstract: Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, Polycomb Repressive Complex 1 (PRC1), has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting activity. In Drosophila, the Posterior Sex Combs (PSC) subunit of PRC1 is central to both activities. The N-terminal homology region (HR) of PSC assembles into PRC1, including partnering with dRING to form the ubiquitin ligase for H2A. The intrinsically disordered C-terminal region of P… Show more

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“…The acetylation-footprinting assay is described in detail in Kang et al 89 . Phase-separation reactions were directly scaled up to use 4 µg of protein for each sample.…”
Section: Methodsmentioning
confidence: 99%
“…The acetylation-footprinting assay is described in detail in Kang et al 89 . Phase-separation reactions were directly scaled up to use 4 µg of protein for each sample.…”
Section: Methodsmentioning
confidence: 99%