DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,2′-bipyridine and 1-phenylpiperazine

ComparativeIn VitroBinding Studies of TiCl2(dpme)2, Ti(ada)2(bzac)2, and TiCl2(bzac)(bpme) Titanium Complexes with Calf-Thymus DNA

“…The IC 50 values of complexes [ 15 , 16 ] 1 , 2 , and 3 are tabulated in Table 1 . Our results corroborate with Pd(II) 2,2′-bipyridine complexes binding to ct-DNA, hyperchromic effect is in same line, and binding constant ( K b ) value was also of almost same magnitude ( K b value of Pd(II) 2,2′-bipyridine complex was 3.78 × 10 3 M −1 ) [ 25 ]. The observed hyperchromism in all the three complexes can be due to the presence of noncovalent interactions, that is, electrostatic interactions, hydrogen binding, and groove binding (major or minor) with outside the ct-DNA structure recommends the binding of complexes and stabilisation of ct-DNA with complexes [ 26 ].…”

Synthesis, DNA binding and complex formation reactions of 3-amino-5,6-dimethyl-1,2,4-triazine with Pd(II) and some selected biorelevant ligands

“…The observed strong hyperchromism is most pronounced in the π-π * transition, indicating that the complex are actively in associating with the DNA. This agrees with the previous study that mentioned that pyridine rings are capable of resting in the minor groove of GC base pairs [21,36].…”

“…Metal complexes may bind to DNA with several different binding modes, namely intercalation or non intercalation, such as groove binding and binding to the phosphate group [21]. In the present study it is assumed that the positively charged diaqua complex would electrostatically interact with the negatively charged phosphate backbone at the periphery of the double helix CT-DNA.…”

Synthesis, structure and in vitro anticancer, DNA binding and cleavage activity of palladium (II) complexes based on isatin thiosemicarbazone derivatives

“…Palladium complexes show approximately 10 4 to 10 5 times higher reactivity, whereas their structural and equilibrium behaviours are very similar to those of platinum complexes. Similarity between the coordination chemistry of platinum(II) and palladium(II) compounds also supports the theory that palladium complexes can act successfully as anti‐tumour drugs . Thus, some palladium complexes with aromatic N‐containing Schiff bases have shown very promising anti‐tumour characteristics .…”