2015
DOI: 10.1016/j.molstruc.2015.06.024
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DNA-binding studies and biological activities of new nitrosubstituted acyl thioureas

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Cited by 34 publications
(11 citation statements)
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“…Some derivatives show interesting applications as biologically active compounds [12][13][14][15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…Some derivatives show interesting applications as biologically active compounds [12][13][14][15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…Thioureas show various biological activities (Yao et al, 2012;Kocyigit-Kaymakcioglu et al, 2013;Korkmaz et al, 2015;Yang et al, 2015;Tahir et al, 2015;Shakeel et al, 2016) and therefore their syntheses are always of interest (Kong et al, 2015;Nguyen et al, 2014;Maki et al, 2014;Chau et al 2014;Maddani & Prabhu, 2010). The X-ray crystal structures of some 1-(2-bromophenyl)-3,3-dimethylthiourea derivatives have been published recently (El-Hiti et al, 2014, 2017: as part of our ongoing studies in this area, we now describe the synthesis and structure of the title compound.…”
Section: Structure Descriptionmentioning
confidence: 92%
“…Viscosity measurement of DNA is regarded a classic way to assess the DNA type of interaction in solution. Under the normal conditions, ethidium bromide (EB), as a known example of intercalators, usually results in a considerable enhancement in DNA viscosity which results from the increase in the distance detaching the intercalation site base pairs that result in a final augmentation in the DNA length [38][39][40], as obvious in Figure 2. For compounds 1 and 5, the obtained results suggest that the compounds under study can intercalate among the adjacent DNA base pairs, resulting in elongation in the double spiral and subsequently raising the DNA viscosity.…”
Section: Viscosity Measurementsmentioning
confidence: 99%