DNA Carrier-Assisted Molecular Ping-Pong in an Asymmetric Nanopore

Zheng, Fei; Alawami, Mohammed; Zhu, Jinbo; Platnich, Casey M.; Sha, Jingjie; Keyser, Ulrich F.; Chen, Kaikai

doi:10.1021/acs.nanolett.3c03605

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…The value of a stable current trace was ∼2.64 nA, with noisy fluctuations. We observed the signals of nanobubble translocations, typically featuring low-amplitude pulse signals similar to that caused by molecules and particles. , …”

Section: Resultsmentioning

confidence: 92%

Single-Digit Nanobubble Sensing via Nanopore Technology

Liu,

Zheng,

et al. 2024

Anal. Chem.

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Nanobubbles play an important role in diverse fields, including engineering, medicine, and agriculture. Understanding the characteristics of individual nanobubbles is essential for comprehending fluid dynamics behaviors and advancing nanoscale science across various fields. Here, we report a strategy based on nanopore sensors for characterizing single-digit nanobubbles. We investigated the sizes and diffusion coefficients of nanobubbles at different voltages. Additionally, the finite element simulation and molecular dynamics simulation were introduced to account for counterion concentration variation around nanobubbles in the nanopore. In particular, the differences in stability and surface charge density of nanobubbles under various solution environments have been studied by the ion-stabilized model and the DLVO theory. Additionally, a straightforward method to mitigate nanobubble generation in the bulk for reducing current noise in nanopore sensing was suggested. The results hold significant implications for enhancing the understanding of individual nanobubble characterizations, especially in the nanofluid field.

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Section: Resultsmentioning

confidence: 92%

Single-Digit Nanobubble Sensing via Nanopore Technology

Liu,

Zheng,

et al. 2024

Anal. Chem.

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Surface Roughness Effects on Confined Nanoscale Transport of Ions and Biomolecules

Ma,

Zheng,

et al. 2023

Small Methods

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Biological channels, especially membrane proteins, play a crucial role in metabolism, facilitating the transport of nutrients and other materials across cell membranes in a bio‐electrolyte environment. Artificial nanopores are employed to study ion and biomolecule transport behavior inside. While the non‐specific interaction between the nanopore surface and transport targets has garnered significant attention, the impact of surface roughness is overlooked. In this study, Nanopores with different levels of inner surface roughness is created by adjusting the FIB (Focus Ion Beam) fabrication parameters. Experiments and molecular dynamics (MD) simulations are employed to demonstrate that greater roughness results from larger FIB beam currents and shorter processing times. Lower roughness increases the capture rate of biomolecules, while greater roughness enhances the normalized blockade current (ΔI/I0). The phenomenon of rougher nanopores are attributed to a barrier‐dominated capture mechanism and more likely to induce DNA folding. This transport barrier exists in rough nanopores by utilizing steer molecular dynamics (SMD) simulations to investigate the force profile of a dA10 DNA molecule during translocation is demonstrated. This work illustrates how surface roughness influences the ionic current features and the translocation of biomolecules, paving a new way for tunning the molecule transport in nanopores.

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Exploring the onset field strength of nanoscale electrospray: A detailed investigation

Zheng,

Wu,

2024

Chemical Physics Letters

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DNA Carrier-Assisted Molecular Ping-Pong in an Asymmetric Nanopore

Cited by 10 publications

References 37 publications

Single-Digit Nanobubble Sensing via Nanopore Technology

Single-Digit Nanobubble Sensing via Nanopore Technology

Surface Roughness Effects on Confined Nanoscale Transport of Ions and Biomolecules

Exploring the onset field strength of nanoscale electrospray: A detailed investigation

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