DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics

Abstract

Metal (especially gold) nanoparticles exhibit unique electronic, optical, and catalytic properties. In order to utilize these properties, an integration of the particles into technical setups such as a chip surface is helpful. We develop techniques to use (bio) molecular tools in order to address and control the positioning of particles on microstructured chips. These techniques are utilized for novel DNA detection schemes using optical or electrical principles. Plasmonic properties of the particles and the combination of nano-apertures with particles are promising fields for further bioanalytical developments.On the other hand, methods for defined positioning of single molecules or molecular constructs in parallel approaches are under development, in order to provide needed defined nanostructures for applications in nanoelectronics. Connecting DNA with nanoparticles, metallization of DNA or positioning of individual DNA-structures over microstructured electrode gap including subsequent metal particle binding are important steps in this direction. The utilization of (bio) molecular tools and principles based on highly specific binding and self-assembly represent a promising development in order to realize novel nanoparticle-based devices for bioanalytics, nano-optics andelectronics.

Tandem Mass Spectrometry of Thiolate-Protected Au Nanoparticles NaxAu25(SC2H4Ph)18−y(S(C2H4O)5CH3)y

“…The importance of our understanding of design and fabrication of nanoparticles has steadily increased as their potential applications have spread, − as for instance in biomedical − drug delivery transporters that rely on specific functionalities. Detailed chemical composition information for almost all such nanoparticle systems, such as gold nanoparticles protected by organothiolate ligand shells, is lacking; properties reported represent average data sets and lack molecular resolution.…”