2017
DOI: 10.1371/journal.pone.0189907
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DNA content analysis allows discrimination between Trypanosoma cruzi and Trypanosoma rangeli

Abstract: Trypanosoma cruzi, a human protozoan parasite, is the causative agent of Chagas disease. Currently the species is divided into six taxonomic groups. The genome of the CL Brener clone has been estimated to be 106.4–110.7 Mb, and DNA content analyses revealed that it is a diploid hybrid clone. Trypanosoma rangeli is a hemoflagellate that has the same reservoirs and vectors as T. cruzi; however, it is non-pathogenic to vertebrate hosts. The haploid genome of T. rangeli was previously estimated to be 24 Mb. The pa… Show more

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“…It is worth highlighting the lack of gDNA detection in Leishmania species (Leishmania donovani and Leishmania infantum), although future studies would involve testing many more Leishmania species since coinfection with T. cruzi is a frequently occurring problem, especially in certain areas of the American continent. Moreover, trypanosomatid genomes share a high level of synteny [38,39].…”
mentioning
confidence: 99%
“…It is worth highlighting the lack of gDNA detection in Leishmania species (Leishmania donovani and Leishmania infantum), although future studies would involve testing many more Leishmania species since coinfection with T. cruzi is a frequently occurring problem, especially in certain areas of the American continent. Moreover, trypanosomatid genomes share a high level of synteny [38,39].…”
mentioning
confidence: 99%