1970
DOI: 10.1159/000224503
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DNA Content and Chromosome Number in Twenty–five Human Carcinomas

Abstract: The author reports the mean DNA values of interphase nuclei in 25 human tumours of epithelial origin, not previously treated. These values are closely related to the chromosome numbers. The constancy of the observed values for each tumour makes it likely that each tumour represents a clone, derived perhaps from one single cell, in which the genetic changes first occurred. The analysis of tumour cell karyotypes indicates, in agreement with DNA estimations, that the mean chromosome size in tumour cells is larger… Show more

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Cited by 15 publications
(1 citation statement)
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“…The same findings were applicable to colorectal cancer (35) and associated multiploidy (or heterogeneity in DNA content) to genuine tumor progression. Comparison of static cytophotometric estimates of DNA content to CG data in the past had revealed quantitative discrepancies (2,32). Later studies based on FCM estimates of DNA quantity have confirmed this finding, at least for bladder cancer (38,451.…”
mentioning
confidence: 98%
“…The same findings were applicable to colorectal cancer (35) and associated multiploidy (or heterogeneity in DNA content) to genuine tumor progression. Comparison of static cytophotometric estimates of DNA content to CG data in the past had revealed quantitative discrepancies (2,32). Later studies based on FCM estimates of DNA quantity have confirmed this finding, at least for bladder cancer (38,451.…”
mentioning
confidence: 98%