1995
DOI: 10.1006/abbi.1995.1493
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DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes

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Cited by 265 publications
(130 citation statements)
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“…4). As previously reported (22)(23)(24)(25)(26)(27), peroxynitrite caused a marked increase in DNA single strand breakage in the J774 cells (Fig. 5).…”
Section: Fig 1 Effect Of Meg Ged S-methyl-meg and Aminoguanidinesupporting
confidence: 87%
See 1 more Smart Citation
“…4). As previously reported (22)(23)(24)(25)(26)(27), peroxynitrite caused a marked increase in DNA single strand breakage in the J774 cells (Fig. 5).…”
Section: Fig 1 Effect Of Meg Ged S-methyl-meg and Aminoguanidinesupporting
confidence: 87%
“…Although the biological activity and decomposition of peroxynitrite are very much dependent on cellular or chemical environment (concentration of proteins, thiols, glucose, and carbon dioxide and the ratio of NO to superoxide) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11), peroxynitrite is now generally considered a more toxic species than either NO or superoxide anion alone (12)(13)(14)(15)(16)(17)(18)(19). The cytotoxic processes triggered by peroxynitrite include initiation of lipid peroxidation (5,15,16), inhibition of mitochondrial respiration (5,12,(17)(18)(19), inhibition of membrane pumps (20), depletion of glutathione (21), and damage to DNA (22)(23)(24)(25) with subsequent activation of poly(ADP-ribose) synthetase and concomitant cellular energy depletion (25)(26)(27).…”
mentioning
confidence: 99%
“…Furthermore, although 8-oxoGua does not readily depurinate, this lesion is chemically labile toward further oxidation and/or nitration, and several secondary lesions have been identified (Chart 1) (14,15). These include guanidinohydantoin (Gh) and its isomer iminoallantoin (Ia) (16), the two diastereomers of spiroiminodihydantoin (Sp) (17,18), oxaluric acid (Oa) (19,20), urea (Ur) (21), N-nitrodehydroguanidinohydantoin (NO 2 -DGh) (22), dehydroguanidinohydantoin (DGh) (23,24), 2,4,6-trioxo [1,3,5]triazinane-1-carboxamidine (CAC) (25), 4-hydroxy-2,5-dioxoimidazolidine-4-carboxylic acid (HICA) (26,27), cyanuric acid (Ca) (25,28), oxazolone (Oz) (29), imidazolone (Iz) (23), and 2-amino-4-hydroxy-s-triazine-6-carboxylic acid (triazine) (30,31).…”
Section: Introductionmentioning
confidence: 99%
“…After treatment with SIN-1, the oligonucleotide products were resolved by HPLC, characterized by mass spectrometry, probed for piperidine lability, and assayed for recognition and strand cleavage by the base-excision repair enzyme MutM. To complement the physical and biochemical characterizations of the oligonucleotide 1 Abbreviations: NI, 5-guanidino-4-nitroimidazole; 8-NO 2 -Gua, 8-nitroguanine; 8-oxoGua, 7,8-dihydro-8-oxoguanine; Gh, guanidinohydantoin; Ia, iminoallantoin; Sp, spiroiminodihydantoin; Oa, oxaluric acid; Ur, urea; NO 2 -DGh, Nnitrodehydroguanidinohydantoin; DGh, dehydroguanidinohydantoin; CAC, 2,4,6-trioxo [1,3,5]triazinane-1-carboxamidine; HICA, 4-hydroxy-2,5-dioxoimidazolidine-4-carboxylic acid; Ca, cyanuric acid; Oz, oxazolone; Iz, imidazolone; triazine, 2-amino-4-hydroxy-striazine-6-carboxylic acid; SIN-1, 3-morpholinosydnonimine; MALDI-TOF-MS, matrix-assisted laser desorption/ionization time-offlight mass spectrometry; ESI-MS, electrospray ionization mass spectrometry. products, each product was incorporated into M13 bacteriophage genomes for analysis of lesion mutagenicity and genotoxicity in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7] The wellestablished notion that peroxynitrite is a highly reactive nitrogen species has long been considered as a straightforward indication that the deleterious effects mediated by this species are entirely ascribable to its direct interactions with target biomolecules. These effects include lipid peroxidation, 8 protein nitration and nitrosylation, 9 DNA damage 10 and oxidation of thiols, 11 and are thought to result in mitochondrial dysfunction and cytotoxicity. [12][13][14][15] Since peroxynitrite very rapidly decomposes at physiological pH values, 16 its effects on target biomolecules should then be produced within a few seconds after addition to cultured cells, i.e., the time required for its disappearance from the intra-extracellular media.…”
Section: Introductionmentioning
confidence: 99%