DNA damage by sodium arsenite in experimental rats: ameliorative effects of antioxidant vitamins C and E

Balakumar, Bharathi

doi:10.17485/ijst/2010/v3i3.12

Cited by 16 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic use of arsenic may cause severe health‐destructive effects including melanosis, hyperkeratosis, lung disease, peripheral vascular disease (blackfoot disease) and gangrene (Das et al., ). Arsenic is a well‐known human carcinogen (Balakumar, Ramanathan, Kumaresan, & Suresh, ) and is capable of provoking malformations in male reproductive system (Chang et al., ; Das, Ghosh, Manna, Sinha, & Parames, ). Sodium arsenite‐induced reproductive toxicity is responsible for the decrease in testes and accessory sex organ weights (Ahmad, Akhar, & Hussain, ).…”

Section: Introductionmentioning

confidence: 99%

Review on arsenic-induced toxicity in male reproductive system and its amelioration

2017

View full text Add to dashboard Cite

Arsenic is an environmental toxicant which causes mutagenic, teratogenic and carcinogenic defects. It is used as herbicide, fungicide and rodenticide and results in contamination of air, soil and water. Arsenic is also produced through burning of coal industries. The sludge of factories contaminates the fodder and drinking source of water of human and livestock. Arsenic binds thiol groups in tissue proteins and impairs the function of the proteins. This metal affects the mitochondrial enzymes and interrupts the production of energy. Oxidative stress and the generation of reactive oxygen species could also be a consequence of arsenic exposure. High arsenic level may suppress the sensitivity of gonadotroph cells to GnRH as well as gonadotropin secretion by elevating plasma levels of glucocorticoids. These ultimately lead to the development of gonad toxicity in animals and cause the reduction in sperm number, sperm viability and motility. Massive degeneration of germ cells and alterations in the level of LH, FSH and testosterone are also reported. The objective of this review was to find out the effects of arsenic-induced toxicity on male reproductive system in animals and its amelioration.

show abstract

Section: Introductionmentioning

confidence: 99%

Review on arsenic-induced toxicity in male reproductive system and its amelioration

2017

View full text Add to dashboard Cite

show abstract

“…Different experiments have indicated severe gonadal harm in different animals during spermatogenesis following exposure to heavy metals (Mandal and Das, 2012;Mahajan et al, 2018). In addition, arsenic is a notable human cancer-causing agent (Balakumar et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells ameliorate the damages induced by arsenic trioxide in the testis of rats

Atia

2020

International Journal of Cancer and Biomedical Research

View full text Add to dashboard Cite

It is with great pleasure that I write this editorial to welcome you to the IJCBR. This journal provides a platform for publication of original and reviews research articles, short communications, letter to editor, thesis abstract, conference report, and case studies. These types of publication are directed at the interface of the fields of cancer and biomedical research.The IJCBR relies on a distinguished expert of the Advisory and Editorial Board Members from the top international league covering in depth the related topics. They timely review all manuscripts and maintain highest standards of quality and scientific methodology and ethical concepts. Meanwhile, we take all possible means to keep the time of the publication process as short as possible.I take this chance to welcome your contributions to the IJCBR and have every expectation that it will soon become one of the most respected journals in both the fields of cancer and biomedical research.

show abstract

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

et al. 2014

View full text Add to dashboard Cite

We explored whether nanoformulation of curcumin can cause better protective effect than free curcumin against arsenic-induced genotoxicity. Curcumin-loaded Poly(lactic-co-glycolic acid) nanoparticles (CUR-NP) were prepared by emulsion technique. The CUR-NP were water soluble and showed biphasic release pattern. Rats were divided into 5 groups of 6 each. Group I served as the control. Group II rats were exposed to sodium arsenite (25 ppm) daily through drinking water for 42 days. Groups III, IV and V were maintained as in Group II, however, they were also administered empty nanoparticle, curcumin (100 mg/kg bw) and CUR-NP (100 mg/kg bw), respectively, by oral gavage during the last 14 days of arsenic exposure. On the 43rd day, genotoxic effects were evaluated in bone marrow cells. Arsenic increased chromosomal aberrations, micronuclei formation and DNA damage. Both free curcumin and CUR-NP attenuated these arsenic-mediated genotoxic effects. However, the result suggests that nanoformulation have better protective effect than free curcumin at the same dose level.

show abstract

DNA damage by sodium arsenite in experimental rats: ameliorative effects of antioxidant vitamins C and E

Cited by 16 publications

References 0 publications

Review on arsenic-induced toxicity in male reproductive system and its amelioration

Review on arsenic-induced toxicity in male reproductive system and its amelioration

Adipose-derived mesenchymal stem cells ameliorate the damages induced by arsenic trioxide in the testis of rats

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

Contact Info

Product

Resources

About