DNA damage induced by carbon ions (C<sup>3+</sup>) beam accessed by independent component analysis of infrared spectra

Raposo, Maria; Coelho, Margarida; Gomes, Paulo J.; Vieira, Pedro; Ribeiro, Paulo A.; Mason, Nigel J.; Hunniford, Christopher; McCullough, Robert

doi:10.3109/09553002.2014.892650

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…This technique was applied to analyze minimal changes in the spectra [28] caused by the effect of the wavelength irradiation on the dye molecules with and without DNA. For the two-dimensional correlation spectroscopy the software 2D Shige 1.3 was used, free software developed by Shigeaki Morita (Osaka Electro-Communication University, Osaka, Japan) [29,30].…”

Section: Irradiation Studiesmentioning

confidence: 99%

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

Pivetta,

Ribeiro,

Raposo

2024

Biophysica

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As a vital biomolecule, DNA is known as a target of antineoplastic drugs for cancer therapy. These drugs can show different modes of interaction with DNA, with intercalation and groove binding being the most common types. The intercalation of anticancer drugs with DNA can lead to the disruption of its normal function, influencing cell proliferation. Methylene blue (MB) and acridine orange (AO) are examples of DNA-intercalating agents that have been studied for their application against some types of cancer, mainly for photodynamic therapy. In this work, the impact of light irradiation on these compounds in the absence and presence of DNA was analyzed by means of UV-vis spectroscopy. Bathochromic and hypochromic shifts were observed in the absorbance spectra, revealing the intercalation of the dyes with the DNA base pairs. Dyes with and without DNA present different profiles of photodegradation, whereby the dyes alone were more susceptible to degradation. This can be justified by the intercalation of the dyes on the DNA base pairs allowing the DNA molecule to partially hinder the molecules’ exposition and, therefore, reducing their degradation.

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Section: Irradiation Studiesmentioning

confidence: 99%

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

Pivetta,

Ribeiro,

Raposo

2024

Biophysica

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Effect of Epigallocatechin-3-gallate on DMPC Oxidation Revealed by Infrared Spectroscopy

Pires

Rodrigues

Magalhães-Mota

et al. 2020

Computational Intelligence Methods for Bioinformatics and Biostatistics

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On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation

Pires

Geraldo

Antunes

et al. 2019

Colloids and Surfaces B: Biointerfaces

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DNA damage induced by carbon ions (C³⁺) beam accessed by independent component analysis of infrared spectra

Abstract: Damage on DNA bases is consistent with the formation of oxime products which react with DNA deoxyribose products forming furfural groups and confirming that DNA damage is caused by direct and indirect processes.

Cited by 3 publications

References 29 publications

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

Effect of Epigallocatechin-3-gallate on DMPC Oxidation Revealed by Infrared Spectroscopy

On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation

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DNA damage induced by carbon ions (C3+) beam accessed by independent component analysis of infrared spectra

Abstract: Damage on DNA bases is consistent with the formation of oxime products which react with DNA deoxyribose products forming furfural groups and confirming that DNA damage is caused by direct and indirect processes.

Cited by 3 publications

References 29 publications

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

The Effect of UV-Vis Radiation on DNA Systems Containing the Photosensitizers Methylene Blue and Acridine Orange

Effect of Epigallocatechin-3-gallate on DMPC Oxidation Revealed by Infrared Spectroscopy

On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation

Contact Info

Product

Resources

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DNA damage induced by carbon ions (C³⁺) beam accessed by independent component analysis of infrared spectra