1990
DOI: 10.1007/bf01971842
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DNA damage induced by doxorubicin, 4′-epidoxorubicin and their copper(II) complexes

Abstract: Abstract. The DNA-damaging activities of doxorubicin (DXR) and 4"-epidoxorubicin (4'epiDXR) were tested on a covalently closed circular plasmid. In the presence of a reducing agent (sodium borohydride), DXR and 4'epiDXR produced similar dose-dependent alterations of the electrophoretic pattern of DNA fragments. Since transition metal ions are known to catalyze this effect, the effects of Cu(II)DXR and Cu(II)epiDXR were also tested. When the Cu(II)-anthracycline complexes were formed at a drug:metal ratio of 2:… Show more

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Cited by 5 publications
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“…Results obtained with this complex were compared with Cu(II) complexes of DOX with regard to semiquinone formation, DNA interaction and action on DNA topoisomerase enzymes to realize its potential as an anticancer agent. 31…”
Section: Introductionmentioning
confidence: 99%
“…Results obtained with this complex were compared with Cu(II) complexes of DOX with regard to semiquinone formation, DNA interaction and action on DNA topoisomerase enzymes to realize its potential as an anticancer agent. 31…”
Section: Introductionmentioning
confidence: 99%
“…It is well-known that DOX can trigger a series of toxic effects on cancer cells, including cell apoptosis and DNA damage. [45,46] To further investigate whether intracellular DOX carried and released by DHAPNs induced such toxic effects in drug-resistant cells, we examined these toxic effects in MCF-7/ ADR cells, using MCF-7 cells as the control. As revealed by Annexin V-FITC/PI double staining assay, DOX triggered negligible apoptosis and necrosis in drug-resistant MCF-7/ADR cells (Figure 3A).…”
Section: Effective Delivery Of Dox By Hapns Into Mcf-7/adr Cells To Exert Antitumor Efficacymentioning
confidence: 99%