DNA damage, repair monitoring and epigenetic DNA methylation changes in seedlings of Chernobyl soybeans

Georgieva, Mariyana; Rashydov, Namik M.; Hajdúch, Marián

doi:10.1016/j.dnarep.2016.12.002

Cited by 40 publications

(25 citation statements)

References 57 publications

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“…In a precise time frame following DNA repair, transcription further remodels the methylation landscape, generating polymorphic methylation profiles that are transmitted to daughter cells. This association between DNA damage, repair, and methylation has been validated in several biological systems and cells [8][9][10].…”

Section: Introductionmentioning

confidence: 79%

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Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

et al. 2020

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Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing frequently occurs due to DNA methylation of the promoter regions, although the underlying mechanism is currently unknown. We present evidence that methylation of p16INK4a promoter is associated with DNA damage caused by interference between transcription and replication processes. Inhibition of replication or transcription significantly reduces the DNA damage and CpGs methylation of the p16INK4a promoter. We conclude that de novo methylation of the promoter regions is dependent on local DNA damage. DNA methylation reduces the expression of p16INK4a and ultimately removes this barrier to oncogene-induced senescence.

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Section: Introductionmentioning

confidence: 79%

“…between DNA damage, repair, and methylation has been validated in several biological systems and cells [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

et al. 2020

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“…Overall the range of studies of the epigenetic response of species to radionuclide exposure in the laboratory point to a role of the epigenome in adaptive responses. The field studies with plants (pine trees and Arabidopsis) showed the potential for ionising radiation to induce changes in DNA methylation levels under field conditions (Georgieva et al 2017;Kovalchuk et al 2003;Kovalchuk et al 2004). For invertebrates, the laboratory and studies in the CEZ and FEZ have partially supported a role of increased methylation in response to radiation among the majority of species studied to date.…”

Section: Evidence For a Role Of Epigenetics In Long-mentioning

confidence: 99%

Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context

Horemans

Spurgeon

Lecomte-Pradines

et al. 2019

Environmental Pollution

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives| 4.0 International License

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“…Among mechanisms which the most likely trigger the adaptation process belong the upregulation of DNA repairs such single and double strand breaks (Boubriak et al, 2016). For instance, Georgieva et al (2016) in Arabidopsis plants Boubriak et al, 2016).…”

Section: Stress Factors and Transposon Activationmentioning

confidence: 99%

Radioactive contamination in Chernobyl and (epi)genetic stability of plants – A review

Lancíková¹,

Žiarovská²

2020

j. cent. eur. agric.

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Rapid industrial and agricultural development brought, besides the indisputable advances, also risks related to the environmental pollution. Widespread soil deterioration represents a global problem. Chernobyl area contaminated by radionuclides after nuclear accident in 1986 provides the opportunity to analyze in situ the impact of radiation on plant systems. Unlike animals and humans, plants are not able to move to another place with better living conditions. Therefore, plants are an ideal object to study adaptation to the conditions of environmental stress. Long-term exposure to the ionizing radiation causes widespread changes in plant genome and epigenome. Also, these alterations may result in changed phenotype. In particular, this review discusses the effect of ionizing radiation on genetic and epigenetic stability of plant genome.

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DNA damage, repair monitoring and epigenetic DNA methylation changes in seedlings of Chernobyl soybeans

Cited by 40 publications

References 57 publications

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context

Radioactive contamination in Chernobyl and (epi)genetic stability of plants – A review

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