DNA damage, serum metabolomic alteration and carcinogenic risk associated with low-level air pollution

Xu, Jiayu; Liu, Yu; Zhang, Qiaojian; Su, Zekang; Yan, Tenglong; Zhou, Shiyong; Wang, Tiancheng; Wei, Xuetao; Chen, Zhangjian; Hu, Guiping; Chen, Tian

doi:10.1016/j.envpol.2021.118763

Cited by 18 publications

(8 citation statements)

References 85 publications

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“…In a group of rats exposed to outdoor air pollution (containing, inter alia, As), a higher concentration of N-acetyl-D-glucosamine in the serum was also observed than in the control group. Moreover, this metabolite was positively related to the phosphorylation of H2AX at Ser 139 (γ-H2AX) in the lungs, which is one of the biomarkers of deoxyribonucleic acid (DNA) damage [ 34 ]. Interestingly, the oral administration of N-acetyl-D-glucosamine in mice increased DNA damage in the pancreas, brain, kidney, liver, lungs, and colon.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Changes and Their Associations with Selected Nutrients Intake in the Group of Workers Exposed to Arsenic

et al. 2023

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Arsenic (As) exposure causes numerous adverse health effects, which can be reduced by the nutrients involved in the metabolism of iAs (inorganic As). This study was carried out on two groups of copper-smelting workers: WN, workers with a urinary total arsenic (tAs) concentration within the norm (n = 75), and WH, workers with a urinary tAs concentration above the norm (n = 41). This study aimed to analyze the association between the intake level of the nutrients involved in iAs metabolism and the signal intensity of the metabolites that were affected by iAs exposure. An untargeted metabolomics analysis was carried out on urine samples using liquid chromatography–mass spectrometry, and the intake of the nutrients was analyzed based on 3-day dietary records. Compared with the WN group, five pathways (the metabolism of amino acids, carbohydrates, glycans, vitamins, and nucleotides) with twenty-five putatively annotated metabolites were found to be increased in the WH group. In the WN group, the intake of nutrients (methionine; vitamins B2, B6, and B12; folate; and zinc) was negatively associated with six metabolites (cytosine, D-glucuronic acid, N-acetyl-D-glucosamine, pyroglutamic acid, uridine, and urocanic acid), whereas in the WH group, it was associated with five metabolites (D-glucuronic acid, L-glutamic acid, N-acetyl-D-glucosamine, N-acetylneuraminic acid, and uridine). Furthermore, in the WH group, positive associations between methionine, folate, and zinc intake and the signal intensity of succinic acid and 3-mercaptolactic acid were observed. These results highlight the need to educate the participants about the intake level of the nutrients involved in iAs metabolism and may contribute to further considerations with respect to the formulation of dietary recommendations for people exposed to iAs.

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Section: Discussionmentioning

confidence: 99%

Metabolic Changes and Their Associations with Selected Nutrients Intake in the Group of Workers Exposed to Arsenic

et al. 2023

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“…Different from epidemiology studies, toxicological approaches apply simulated exposures such as PM nasal instillation, blood injection, or reaerosolization after enrichment . Additionally, investigation of single pollutants could neglect the important synergistic health effects of different pollutants present in natural air. − Besides, in those toxicological studies, tedious efforts were carried out to study the health impacts such as analysis of tissues, blood biomarkers, − metabolome, , and transcriptome . These methods are offline, while consisting of invasive and complex procedures; and unable to provide timely health impact information about air pollution.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Monitoring of Air Pollution Health Impacts Using Breath-Borne Gaseous Biomarkers from Rats

Zhu,

Yao

2024

Environ. Sci. Technol.

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Offline techniques are adopted for studying air pollution health impacts, thus failing to provide in situ observations. Here, we have demonstrated their real-time monitoring by online analyzing an array of gaseous biomarkers from rats' exhaled breath using an integrated exhaled breath array sensor (IEBAS) developed. The biomarkers include total volatile organic compounds (TVOC), CO 2 , CO, NO, H 2 S, H 2 O 2 , O 2 , and NH 3 . Specific breath-borne VOCs were also analyzed by a gas chromatography-ion mobility spectrometer (GC-IMS). After real-life ambient air pollution exposures (2 h), the pollution levels of PM 2.5 and O 3 were both found to significantly affect the relative levels of multiple gaseous biomarkers in rats' breath. Eleven biomarkers, especially NO, H 2 S, and 1-propanol, were detected as significantly correlated with PM 2.5 concentration, while heptanal was shown to be significantly correlated with O 3 . Likewise, significant changes were also detected in multiple breath-borne biomarkers from rats under labcontrolled O 3 exposures with levels of 150, 300, and 1000 μg/m 3 (2 h), compared to synthetic air exposure. Importantly, heptanal was experimentally confirmed as a reliable biomarker for O 3 exposure, with a notable dose−response relationship. In contrast, conventional biomarkers of inflammation and oxidative stress in rat sera exhibited insignificant differences after the 2 h exposures. The results imply that breath-borne gaseous biomarkers can serve as an early and sensitive indicator for ambient pollutant exposure. This work pioneered a new research paradigm for online monitoring of air pollution health impacts while obtaining important candidate biomarker information for PM 2.5 and O 3 exposures.

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“…Reactive oxygen species (ROS) levels can significantly increase as a response to heavy metals and PAH exposure. ROS can thus lead to oxidative stress and oxidative DNA damage, which basically consist of the formation of lesions to DNA filaments [ 14 ]. However, the effects of exposure to heavy metals and PAH may be different, potentially depending on the health status of the individual [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Presence of Ultra-Traces of Persistent Organic Pollutants (POPs) and Heavy Metals in Some Areas of Molise: The Importance of a “Blank” in Public Health Studies

Notardonato

Fantasma

Monaco

et al. 2023

Toxics

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The emission of chemicals into the environment has increased in a not negligible way as a result of the phenomenon of globalization and industrialization, potentially also affecting areas always considered as “uncontaminated”. In this paper, five “uncontaminated” areas were analyzed in terms of the presence of polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs), comparing them with an “environmental blank”. Chemical analyses were carried out using standardized protocols. The ‘environmental blank’ results revealed the presence of Cu (<64.9 μg g−1), Ni (<37.2 μg g−1), and Zn (<52.6 μg g−1) as HMs and fluorene (<17.0 ng g−1) and phenanthrene (<11.5 ng g−1) as PAHs. However, regarding the results of the pollution status of the areas under study, fluorene (#S1, 0.34 ng g−1; #S2, 4.3 ng g−1; #S3, 5.1 ng g−1; #S4, 3.4 ng g−1; #S5, 0.7 ng g−1) and phenanthrene (#S1, 0. 24 ng g−1; #S2, 3.1 ng g−1; #S3, 3.2 ng g−1; #S4, 3.3 ng g−1; #S5, 0.5 ng g−1) were found in all areas, while the other PAHs investigated were detected at a concentration averaging less than 3.3 ng g−1. HMs were found in all of the investigated areas. In particular, Cd was detected in all areas with an average concentration of less than 0.036 μg g−1, while Pb was absent in area #S5, but present in the other areas with an average concentration of less than 0.018 μg g−1.

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DNA damage, serum metabolomic alteration and carcinogenic risk associated with low-level air pollution

Cited by 18 publications

References 85 publications

Metabolic Changes and Their Associations with Selected Nutrients Intake in the Group of Workers Exposed to Arsenic

Metabolic Changes and Their Associations with Selected Nutrients Intake in the Group of Workers Exposed to Arsenic

Real-Time Monitoring of Air Pollution Health Impacts Using Breath-Borne Gaseous Biomarkers from Rats

The Presence of Ultra-Traces of Persistent Organic Pollutants (POPs) and Heavy Metals in Some Areas of Molise: The Importance of a “Blank” in Public Health Studies

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