DNA damage, sirtuins, and epigenetic marks

Alves-Fernandes, Débora Kristina; Jasiulionis, Miriam Galvonas

doi:10.1016/b978-0-323-91081-1.00016-9

Epigenetics and DNA Damage 2022

DOI: 10.1016/b978-0-323-91081-1.00016-9

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DNA damage, sirtuins, and epigenetic marks

Débora Kristina Alves-Fernandes

Miriam Galvonas Jasiulionis

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Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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Augustyniak

2022

IJMS

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The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries.

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Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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Augustyniak

2022

IJMS

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DNA damage, sirtuins, and epigenetic marks

Cited by 1 publication

References 167 publications

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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