2023
DOI: 10.1002/jcp.31170
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DNA demethylation of promoter region orchestrates SPI‐1‐induced ADAMTS‐5 expression in articular cartilage of osteoarthritis mice

Zhixin Liu,
Tongxin Lu,
Liang Ma
et al.

Abstract: Osteoarthritis (OA) is one of the most prevalent joint diseases in aged people and characterized by articular cartilage degeneration, synovial inflammation, and abnormal bone remodeling. Recent advances in OA research have clearly shown that OA development is associated with aberrant DNA methylation status of many OA‐related genes. As one of most important cartilage degrading proteases in OA, a disintegrin and metalloproteinase with thrombospondin motifs subtype 5 (ADAMTS‐5) is activated to mediate cartilage d… Show more

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