DNA-dependent RNA polymerase in African swine fever virus

Kuznar, Juan; Salas, María; Viñuela, Eladio

doi:10.1016/0042-6822(80)90493-6

Cited by 85 publications

(38 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genome of ASF virus consists of a double-stranded DNA molecule with an approximate molecular weight of 100 x 106 (Enjuanes et al, 1976) and contains $1 nuclease-sensitive cross-links near the ends (Ortin et al, 1979). Because orthopoxviruses also have a terminally cross-linked genome structure and similar virusassociated enzymes (Moss, 1978), Kuznar et al (1980) have suggested that the two virus groups may have a common biochemical strategy for early replication functions.…”

Section: Introductionmentioning

confidence: 99%

African Swine Fever Virus DNA: Restriction Endonuclease Cleavage Patterns of Wild-type, Vero Cell-adapted and Plaque-purified Virus

Wesley

Pan

1982

Journal of General Virology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

African Swine Fever Virus DNA: Restriction Endonuclease Cleavage Patterns of Wild-type, Vero Cell-adapted and Plaque-purified Virus

Wesley

Pan

1982

Journal of General Virology

View full text Add to dashboard Cite

“…Meanwhile, transcription of early genes and posttranscriptional modification of the mRNA occur inside the virion; this is ensured by packaged proteins such as the viral RNA polymerase and, hence, independent of cellular enzymes (37)(38)(39)(40)(41). Late gene expression, however, depends on viral DNA replication and viral early proteins.…”

mentioning

confidence: 99%

DNA Virus Replication Compartments

Schmid

Speiseder

Dobner

et al. 2014

J Virol

158

142

View full text Add to dashboard Cite

bViruses employ a variety of strategies to usurp and control cellular activities through the orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear compartments. Formation of such specialized virus-induced cellular microenvironments, which have been termed viroplasms, virus factories, or virus replication centers, complexes, or compartments, depends on molecular interactions between viral and cellular factors that participate in viral genome expression and replication and are in some cases associated with sites of virion assembly. These virus-induced compartments function not only to recruit and concentrate factors required for essential steps of the viral replication cycle but also to control the cellular mechanisms of antiviral defense. In this review, we summarize characteristic features of viral replication compartments from different virus families and discuss similarities in the viral and cellular activities that are associated with their assembly and the functions they facilitate for viral replication.

show abstract

“…Its genome is formed by a double-stranded DNA molecule of about 170 kbp with hairpin loops and terminal inverted repeats (Gonzfilez et al, 1986;Sogo et al, 1984), similar to those of poxvirus DNA (Baroudy et al, 1982;Wittek & Moss, 1980). Like the poxviruses (Moss, 1990), ASF virus packages a complete enzymatic system for the synthesis of early RNA (Kuznar et al, 1980;Salas et al, 1981Salas et al, , 1986.…”

mentioning

confidence: 99%

African swine fever virus thymidylate kinase gene: sequence and transcriptional mapping

Yáñez

Rodríguez²,

Rodrı́guez³

et al. 1993

Journal of General Virology

View full text Add to dashboard Cite

A putative thymidylate kinase gene of African swine fever virus has been identified at the left end of the Sall I' fragment of the virus genome. The gene, designated A240L, has the potential to encode a protein of 240 amino acids with an M r of 27 754 and is transcribed early after infection. Primer extension analysis indicates that transcription is initiated a short distance from the first ATG codon of open reading frame A240L. The deduced amino acid sequence of this open reading frame shows significant similarity with the human, yeast and vaccinia virus thymidylate kinases, the degree of identity being 23"7, 25 and 23"5 %, respectively. The putative African swine fever virus thymidylate kinase sequence is essentially collinear with the other thymidylate kinase sequences, but contains a carboxy-terminal extension of 37 amino acids rich in glutamic and aspartic acids. The A240L protein conserves the ATP-binding and nucleotide/nucleoside-binding domains characteristic of thymidylate kinases.

show abstract

DNA-dependent RNA polymerase in African swine fever virus

Cited by 85 publications

References 21 publications

African Swine Fever Virus DNA: Restriction Endonuclease Cleavage Patterns of Wild-type, Vero Cell-adapted and Plaque-purified Virus

African Swine Fever Virus DNA: Restriction Endonuclease Cleavage Patterns of Wild-type, Vero Cell-adapted and Plaque-purified Virus

DNA Virus Replication Compartments

African swine fever virus thymidylate kinase gene: sequence and transcriptional mapping

Contact Info

Product

Resources

About