DNA Fingerprinting Profile and Quality Control Standardization of Folklore Medicinal Plant Exacum lawii

Sharma, Sonam; Hemalatha, S

doi:10.5530/pj.2017.6.122

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cisplatin leads to releasing ROS and increasing oxidative stress [7,8]. Reducing the ROS production in renal tissue could protect kidneys from injury of oxidative stress in rats [9]. Our previous research found that mitochondria are the most damaged organelles in CIN [10,11].…”

mentioning

confidence: 99%

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Liang

Yang

et al. 2019

FEBS Open Bio

View full text Add to dashboard Cite

Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive oxygen species (ROS) generation. Our previous studies have indicated that Panax notoginseng saponins (PNSs) mitigate CIN by enhancing hypoxia‐inducible factor 1α (HIF‐1α)‐induced mitochondrial autophagy. In this study, the role of the HIF‐1α/mitochondria/ROS pathway in PNSs protection against CIN was investigated using a rat model. A CIN model was generated by giving rats intraperitoneal injections with cisplatin (a single dose) and then treating them with or without 2‐methoxyestradiol (HIF‐1α inhibitor) and PNSs. We then measured ROS levels, superoxide dismutase, glutathione, catalase malondialdehyde and nitric oxide (to evaluate oxidative stress) and ATP, mitochondrial membrane potential and mitochondrial permeability transition pore opening (to evaluate mitochondrial function) in kidneys at different time points. We observed that PNSs remarkably reduced the levels of ROS, malondialdehyde and nitric oxide, as well as the opening of mitochondrial permeability transition pore, which is increased by cisplatin and further increased by HIF‐1α inhibition. In addition, PNSs increased the levels of superoxide dismutase, catalase and glutathione, as well as ATP and mitochondrial membrane potential in renal tissues; these are all reduced by cisplatin and further reduced by HIF‐1α inhibition. In conclusion, we demonstrate here that PNSs protects against mitochondrial damage induced by cisplatin through HIF‐1α/mitochondria/ROS.

show abstract

mentioning

confidence: 99%

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Liang

Yang

et al. 2019

FEBS Open Bio

View full text Add to dashboard Cite

show abstract

“…However, we know the chemical constituents are susceptible to environmental factors (GOBBO-NETO & LOPES, 2007). Thus, it was necessary to evaluate the genetic structure of C. icaco because Nowadays, DNA fingerprinting has been widely used for documenting genetic diversity of medicinal plants (GANIE et al, 2015;SHARMA & HEMALATHA, 2017). Techniques based on the polymerase chain reaction (PCR) have been described for the authentication of medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Genetic Fingerprinting of the Brazilian Medicinal Plant Chrysobalanus Icaco L. (Chrysobalanaceae) / Impressão Digital Genética Da Espécie Medicinal Brasileira Chrysobalanus Icaco L. (Chrysobalanaceae)

Paracampo

Oliveira

Prance

et al. 2020

BJD

View full text Add to dashboard Cite

show abstract

Brazilian Journal of Development

Bonfim¹

View full text Add to dashboard Cite

DNA Fingerprinting Profile and Quality Control Standardization of Folklore Medicinal Plant Exacum lawii

Cited by 3 publications

References 15 publications

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Genetic Fingerprinting of the Brazilian Medicinal Plant Chrysobalanus Icaco L. (Chrysobalanaceae) / Impressão Digital Genética Da Espécie Medicinal Brasileira Chrysobalanus Icaco L. (Chrysobalanaceae)

Brazilian Journal of Development

Contact Info

Product

Resources

About