DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia

Meggyesházi, Nóra; Andócs, Gábor; Balogh, Lajos; Balla, Péter; Kiszner, Gergő; Teleki, Ivett; Jeney, A.; Krenács, Tibor

doi:10.1007/s00066-014-0617-1

Cited by 72 publications

(94 citation statements)

References 35 publications

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“…4). This delayed effect of the treatment may be associated with mEHT, which is known to elicit delayed apoptotic reactions (41,42) and to improve immunity (43,44), as well as with the TCM. TCM herbal medicines increase the sensitivity of cancer to mEHT and, vice versa, mEHT increases the anticancer effect of herbal medicines (9).…”

Section: Discussionmentioning

confidence: 99%

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Pang¹,

Zhang²,

Wang³

et al. 2017

Molecular and Clinical Oncology

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Abstract. The purpose of this study was to develop a safe and non-toxic alternative to the conventional conservative treatment of peritoneal carcinomatosis with malignant ascites (PCMA) by investigating the efficacy and safety of local modulated electro-hyperthermia (mEHT) combined with the traditional Chinese medicine (TCM) 'Shi Pi' herbal decoction, compared with standard intraperitoneal chemoinfusion (IPCI). A randomized, controlled, single-center, open-label clinical trial (phase II) with two parallel groups (allocation ratio, 1:1) was conducted to investigate the efficacy and safety of mEHT+TCM (study group, SG) vs. standard IPCI (control group, CG) in patients with PCMA by intention-to-treat analysis. A total of 260 patients with PCMA were randomly allocated into the two groups (130/130); mEHT was applied for 60 min per session every second day for 4 weeks, for a total of 14 sessions. The TCM decoction was administered orally, at 400 ml daily. In CG, occlusive IPCI with cisplatin (30-60 mg) and fluorouracil (500-600 mg/m 2 ) was applied twice, biweekly. The objective response rate (ORR), quality of life (QoL) and adverse event rate (AER) in the two groups were evaluated 1 month after treatment, analyzed and compared. The present study is registered on ClinicalTrials.gov (NCT02638051). No case was lost or excluded (0/260). The ORR in SG was 77.69% (101/130) vs. 63.85% (73/130) in CG (P<0.05). The QoL in SG was 49.23% vs. 32.3% in CG (P<0.05). The AER in SG was 2.3% (3/130) vs. 12.3% (16/130) in CG (P<0.05). All the adverse events were grade I. In conclusion, the combination of mEHT with TCM achieves better control of PCMA compared with standard IPCI, with less toxicity. Both components of the combination are non-toxic treatments easily tolerated by patients. Thus, this combined treatment may be preferred due to the better benefit-harm balance.

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Section: Discussionmentioning

confidence: 99%

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Pang¹,

Zhang²,

Wang³

et al. 2017

Molecular and Clinical Oncology

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“…Next, Ca 2+ influx into the cell (compared to a reference) was measured, which can be connected to TRPV sensing. The results showed the start of Ca 2+ influx at least 3°C earlier in nanothermia 6 ; the direct staining temperature measurement showed the same result [219,220].…”

mentioning

confidence: 61%

What is on the Horizon for Hyperthermic Cancer Therapy?

GyP¹,

Dy²,

Hegyi³

2017

J Tradi Med Clin Natur

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“…The motility of TRPs is greater in the membrane of malignant cells [54], facilitating more TRPs in the high SAR places, allowing the certainly high Ca 2+ influx to the cytoplasm. This changes the homeostatic equilibrium of the actual cell, promoting apoptotic cell death, as observed in mEHT treatments [55,56]. The increased BAX level in the affected cells [55] also indicates this apoptotic effect.…”

Section: Methodsmentioning

confidence: 87%

Nanoheating without Artificial Nanoparticles

Vincze

Andócs

et al. 2015

Biol Med (Aligarh)

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Our aim is to describe the physical and physiological effects of local modulated electro-hyperthermia (mEHT). The method concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster contains transmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in one domain. This targeting is analogous to nanoparticle heating, except this uses readily available nanoparticles on the cell membrane instead of the artificially placed nano-object to induce selective energy absorption from the outside field. In the discussed non-artificial nanoparticle heating, selectivity is the consequence of the synergy of various interactions embedded into each other in their effective volume in macro-, micro-and nano-ranges.

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DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia

Abstract: Modulated EHT treatment can induce programmed cell death-related tumor destruction in HT29 colorectal adenocarcinoma xenografts, which dominantly follows a caspase-independent subroutine.

Cited by 72 publications

References 35 publications

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

What is on the Horizon for Hyperthermic Cancer Therapy?

Nanoheating without Artificial Nanoparticles

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