DNA Hydrogels: DhITACT: DNA Hydrogel Formation by Isothermal Amplification of Complementary Target in Fluidic Channels (Adv. Mater. 23/2015)

Lee, Ho Yeon; Jeong, Hansaem; Jung, Il Young; Jang, Bora; Seo, Young Chang; Lee, Haeshin; Lee, Hyukjin

doi:10.1002/adma.201570154

Cited by 7 publications

(8 citation statements)

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“…Isothermal amplification has been developed using various combinations of enzymes and nucleic acid probes. Furthermore, many studies utilizing isothermal target amplification have been implemented in chip-based applications, e.g., rolling circle amplification (RCA), [136][137][138] recombinase polymerase amplification (RPA) [139], LAMP [140,141], helicase-dependent amplification (HDA) [142][143][144], and nucleic acid sequence-based amplification (NASBA) [145][146][147].…”

Section: Isothermal Amplification-based Detectionmentioning

confidence: 99%

Total microfluidic platform strategy for liquid biopsy

Lee

Shin

2021

JCB

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A liquid biopsy is a simple and non-invasive biopsy that examines a range of information about a tumor through a simple blood sample. Due to its non-invasive nature, liquid biopsy has many outstanding clinical benefits, including repetitive sampling and examination, representation of whole mutations, observation of minimal residual disease etc. However, liquid biopsy requires various processes such as sample preparation, amplification, and target detection. These processes can be integrated onto microfluidic platforms, which may provide a sample-to-answer system. The present review provides a brief overview of liquid biopsies, a detailed review of the technologies in each process, and prospective concluding remarks. Through this review, one can have a basic but cross-disciplinary understanding of liquid biopsy, as well as knowledge of new starting points for future research in each related area.

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Section: Isothermal Amplification-based Detectionmentioning

confidence: 99%

Total microfluidic platform strategy for liquid biopsy

Lee

Shin

2021

JCB

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“…The metal-insulator-metal (MIM) geometry finds a wide range of applications in optics and enables everything from subwavelength waveguides [1][2][3] and perfect absorbers [4][5][6][7] to color filters [8,9] and spectrometers. [10] The growing need for devices capable of dynamically controlling optical responses in real time has with tunable optical properties such as phase-change vanadium dioxide, [32] Zn-sodium vanadium oxide, [33] electrochromic polymers [34,35] and hydrogel [36] were proposed in lithography-free FP cavities.…”

Section: Introductionmentioning

confidence: 99%

Dynamically Tunable Optical Cavities with Embedded Nematic Liquid Crystalline Networks

et al. 2023

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prompted a renewed interest in asymmetric Fabry-Pérot (FP) cavities, also termed Gires-Tournois resonators. They are comprised of one optically thick and one optically thin metallic mirror through which light can enter the structure. These optical elements are known for their ease of fabrication and effectiveness in resonating and enhancing light-matter interaction at selected wavelengths. [4,6,7] The general strategy to achieve dynamic tuning in FP resonators is to replace the passive insulator that commonly sits between the mirrors by dynamically tunable materials such as graphene, [11][12][13] phase-change magnesium, [14] electro-optical polymers, [15] liquid crystals (LCs) [16][17][18] and conducting oxides [19][20][21] via the field-effect. [22] Several works showed that electrical gating of indium-tin-oxide incorporated in the cavity facilitates control over light absorption [12,19] and its reflection phase in mid-infrared [20] and near-infrared. [21] Other research exploited electrochromic oxide [23] and polymers [24][25][26] with nanostructures to tune the resulting reflected color. Researchers showed that optical pumping of gallium-doped zinc oxide [27] and alumina [28] allows for ultrafast modulation of cavity resonances in a sub-picosecond regime. Tuning can also be achieved in non-conventional ways by light pressure, [29] directed self-assembly of nanoparticles in a liquid electrolyte [30] and by phase-tunable meta-mirrors. [31] To reduce fabrication complexity, a large variety of responsive materials Tunable metal-insulator-metal (MIM) Fabry-Pérot (FP) cavities that can dynamically control light enable novel sensing, imaging and display applications. However, the realization of dynamic cavities incorporating stimuliresponsive materials poses a significant engineering challenge. Current approaches rely on refractive index modulation and suffer from low dynamic tunability, high losses, and limited spectral ranges, and require liquid and hazardous materials for operation. To overcome these challenges, a new tuning mechanism employing reversible mechanical adaptations of a polymer network is proposed, and dynamic tuning of optical resonances is demonstrated. Solid-state temperature-responsive optical coatings are developed by preparing a monodomain nematic liquid crystalline network (LCN) and are incorporated between metallic mirrors to form active optical microcavities. LCN microcavities offer large, reversible and highly linear spectral tuning of FP resonances reaching wavelength-shifts up to 40 nm via thermomechanical actuation while featuring outstanding repeatability and precision over more than 100 heating-cooling cycles. This degree of tunability allows for reversible switching between the reflective and the absorbing states of the device over the entire visible and near-infrared spectral regions, reaching large changes in reflectance with modulation efficiency ΔR = 79%.

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“…It notes that such metal-insulator-metal (MIM) configuration metasurfaces have been suggested as absorbers and realized at various frequencies. [11][12][13][14][15][16] In contrast to previous designs, we incorporate a pyroelectric thin film, poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) copolymer (70/30 molar ratio), [17,18] instead of traditional dielectric materials (such as Al2O3, SiO2 and MgF2) for the dielectric spacer. This change not only brings our design with high performance multiple selective absorption bands resulting from the unique optical properties of the copolymer, but also makes it has great prospects for applications in compact optoelectronic devices such as uncooled LWIR pyroelectric detectors.…”

Section: Introductionmentioning

confidence: 99%

Spatial and Frequency Selective Plasmonic Metasurface for Long Wavelength Infrared Spectral Region

Pan

Gao

et al. 2018

Advanced Optical Materials

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The development of novel approaches that control absorption and emission operating in long wavelength infrared (LWIR) spectral region is of fundamental importance for many applications, such as, remote temperature sensing, environmental monitoring, thermal imaging, radiation cooling and industrial facility inspections. A high performance plasmonic metasurface-based absorber for the LWIR spectral region is presented. In our design, a pyroelectric thin film, poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) copolymer, is introduced as spacer, that offers the device not only with multiple selective high absorption bands but also promising potential for application in optoelectronics. By employing a scattering-type near-field optical microscopy (s-SNOM), both the near-field amplitude and phase optical responses of the absorber are investigated at resonant wavelength, thereby providing direct experimental evidence to verify the nature of the absorption effect. To further demonstrate the versatility of our design, a particular metasurface patterned by the building blocks of the plasmonic absorber is fabricated and characterized. Two-dimensional hyperspectral images show that such a patterned structure exhibits both frequency and spatially selective absorption.

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DNA Hydrogels: DhITACT: DNA Hydrogel Formation by Isothermal Amplification of Complementary Target in Fluidic Channels (Adv. Mater. 23/2015)

Cited by 7 publications

References 0 publications

Total microfluidic platform strategy for liquid biopsy

Total microfluidic platform strategy for liquid biopsy

Dynamically Tunable Optical Cavities with Embedded Nematic Liquid Crystalline Networks

Spatial and Frequency Selective Plasmonic Metasurface for Long Wavelength Infrared Spectral Region

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