DNA index as a significant predictor of recurrence in colorectal cancer

Abstract

The DNA index value (less than or greater than 1.4) seems to be a stronger predictor than DNA ploidy (diploid or aneuploid), and the combination of Dukes stage, tumor site, and a DNA index is, therefore, considered to be clinically valuable in predicting recurrence in cases of colorectal cancer.

DNA Ploidy Status and Prognosis in Colorectal Cancer: A Meta-Analysis of Published Data

“…In these 25 studies, it was observed that the duration of followup was inaccurate or did not reach five years after surgical treatment. Nineteen studies 29,48,[62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] were excluded because of impossible data extraction. In these studies, survival data tables or curves at fiveyear follow-up were not available or absolute death numbers were available but the group size was not determined at the beginning of follow-up or after five years.…”

Correlação de fatores anatomopatológicos com a sobrevida de pacientes operados por adenocarcinoma colorretal

“…À luz do grande avanço no campo dos métodos de imagem, genética e marcadores biomoleculares [30][31][32][33] , os achados anatomopatológicos ainda são, na maioria das vezes, os mais importantes, acessíveis e fundamentais fatores na determinação da sobrevida e decisão sobre a aplicação de terapia adjuvante. Há porém, grande controvérsia na literatura médi-ca quanto a relação de significância de alguns deles com a sobrevida dos pacientes portadores de câncer colorretal.…”

Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer—a meta-analysis and current overview

“…Altogether 8 of 21 studies (38.1 %) stated statistical significance for survival differences with regard to the ploidy status for the entire collective of Dukes stage A to D CRC [35,39,72,40,44,73,38,45]. Out of these, evaluating the individual tumor stages, not more than two stages per study showed significances in survival.…”

“…Twelve of 20 (60 %) studies reported a significant difference in survival with aneuploid tumors implying a worse prognosis in either OS, DSS, or RFS [14,15,32,33,70,63,67,71,38,39,72,40]. There were 12 studies which performed a multivariate analysis for OS.…”

“…Out of these, six described statistical significance for aneuploidy [14,15,63,71,38,41]. For RFS, five studies performed multivariate analysis and two revealed statistical significance for the ploidy status [14,40].…”