2024
DOI: 10.1002/ardp.202400409
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DNA interaction of selected tetrahydropyrimidine and its effects against CCl4‐induced hepatotoxicity in vivo: Part II

Emilija Milović,
Sanja Lj. Matić,
Jelena S. Katanić Stanković
et al.

Abstract: Tetrahydropyrimidine (compound A = methyl 4‐[4′‐(heptyloxy)‐3′‐methoxyphenyl]‐1,6‐dimethyl‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate) was chosen for in vivo studies after exhibiting noteworthy in vitro activity against the K562 and MDA‐MB‐231 cell lines, with IC50 values of 9.20 ± 0.14 µM and 12.76 ± 1.93 µM, respectively. According to experimental (fluorescence titration, viscosity, and differential scanning calorimetry) results, A interacts with DNA via the minor groove. In vivo, acute oral toxicit… Show more

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