DNA interaction of some polymer–copper(II) complexes containing 2,2′-bipyridyl ligand and their antimicrobial activities

Kumar, R. Senthil; Sasikala, K.; Arunachalam, S.

doi:10.1016/j.jinorgbio.2007.08.005

Cited by 75 publications

(12 citation statements)

References 55 publications

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“…Non-covalent DNA interactions include intercalative, electrostatic and groove (surface) binding. Intercalation involves the partial insertion of aromatic heterocyclic rings of the ligands between the DNA base pairs [26]. The spectroscopic techniques of electronic absorption and fluorescence are two of the most useful for DNA-binding studies of small molecules [27].…”

Section: Resultsmentioning

confidence: 99%

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

et al. 2014

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2-Acetylpyridine acetylhydrazone (H2AcMe), 2-benzoylpyridine acetylhydrazone (H2BzMe) and complexes [Cu(H2AcMe)Cl2] (1) and [Cu(H2BzMe)Cl2] (2) were assayed for their cytotoxicity against wild type p53 U87 and mutant p53 T98 glioma cells, and against MRC-5 fibroblast cells. Compounds 1 and 2 proved to be more active than the corresponding hydrazones against U87, but not against T98 cells. Compound 1 induced higher levels of ROS than H2AcMe in both glioma cell lines. H2AcMe and 1 induced lower levels of ROS in MRC5 than in U87 cells. Compound 2 induced lower levels of ROS in MRC5 than in T98 cells. The cytotoxic effect of 1 in U87 cells could be related to its ability to provoke the release of ROS, suggesting that the cytotoxicity of 1 might be somehow p53 dependent.

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Section: Resultsmentioning

confidence: 99%

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

et al. 2014

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“…Previous studies have reported that 2,2′-bipyridyl could increase the antimicrobial property of polymer-Cu(II) complexes by enhancing the lipophilic character of the central metal atom. 50,51 However, most of the antimicrobial activities of 2,2′-bipyridyl were reported when it was combined with other metal ions (e.g., platinum, cobalt, and copper) or with metal complexes. 52,53 It is possible that 2,2′-bipyridyl chelated Fe 3+ and/or other metal ions supplemented in media, which retarded the growth of Salmonella .…”

Section: Discussionmentioning

confidence: 99%

Growth and Virulence of Salmonella Typhimurium Mutants Deficient in Iron Uptake

Tan

Chekabab

et al. 2019

ACS Omega

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The present study investigated the effects of iron, iron chelators, and mutations of tonB or iroN fepA genes on the growth and virulence of Salmonella Typhimurium . Results indicated that organic iron (ferric citrate and ferrous- l -ascorbate) supported better growth of Salmonella compared to inorganic iron. Among tested chelators, 2,2′-bipyridyl at 500 μM showed the highest inhibition of Salmonella growth with 5 μM ferrous sulfate. Deletion of genes ( tonB – and iroN – fepA – ) in the iron uptake system attenuated Salmonella invasion of Caco-2 cells and its ability to damage the epithelial monolayer. The expression of all tested host genes in Caco-2 was not affected under the iron-poor condition. However, claudin 3, tight junction protein 1, tumor necrosis factor α (TNF-α), and interleukin-8 (IL-8) were altered under the iron-rich condition depending on individual mutations. In Caenorhabditis elegans , a significant down-regulation of ferritin 1 expression was observed when the nematode was infected by the wild-type (WT) strain.

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“…However, all of them exhibited lower activity than fluconazole. Another complex containing Cu(II) was found to have good antifungal activity due to electrostatic binding to fungal DNA [72]. (6) Imidazole derivatives, polymers and copolymers, with antimicrobial effectiveness depending on the polymeric structures [71, 142].…”

Section: Need Of New Antifungal Agentsmentioning

confidence: 99%

CandidaInfections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

Spampinato

Leonardi

2013

BioMed Research International

321

261

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The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.

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DNA interaction of some polymer–copper(II) complexes containing 2,2′-bipyridyl ligand and their antimicrobial activities

Cited by 75 publications

References 55 publications

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

Growth and Virulence of Salmonella Typhimurium Mutants Deficient in Iron Uptake

CandidaInfections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

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