DNA interaction studies of Cu(II), Co(II), and Ni(II) chelates derived from schiff base ligand

Ereshanaik,; Prabhakara, M.C.; Naik, H.S. Bhojya; Kirthan, B.R.; Kumaraswamy, H M; Jain, Renuka

doi:10.1016/j.jics.2021.100288

Cited by 9 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Schiff bases are comprising of few important ligands that coordinate with metal ions through azomethine nitrogen to form the complexes [13,14]. The corresponding chelates of Schiff bases have gained significant research interest owing to their ability to stabilize many different metals in various oxidation states [15][16][17][18][19]. They can also be used as an effective corrosion inhibitor since they are capable to form a monolayer spontaneously on the surface of metals [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic and Thermal Characterization and Antioxidant Activities of Three Schiff Bases Derived from Aminophenol

Yekhlef¹,

Benghanem²,

Foudia³

et al. 2023

IJHT

View full text Add to dashboard Cite

The main objective of this work is synthesized three Schiff bases: (E)-2-(((2hydroxyphenyl)imino)methyl)-6-methoxyphenol (I), (E)-2-(((3-hydroxyphenyl) imino)-Methyl)-6-Methoxyphenol(II) and (e)-2-(((4-hydroxyphenyl)imino)methyl)-6amethoxyphenol(III) derivative of 2-hydroxy-3-methoxybenzaldehyde and ortho/meta / para-aminophenol, their structures were confirmed by spectroscopic methods: UV-Vis, FTIR, ( 1 H, 13 C NMR). Firstly, a thermogravimetric analysis (TGA/DTG) study of the composite Schiff bases proved them to be thermally stable. Secondly, the study of the biological properties of the synthesized compounds allowed the evaluation of the antioxidant activity by conventional methods (scavenging of the DPPH radical, and bleaching of ß-carotene). The results demonstrated a variable degree of inhibitory effects on the growth of synthesized Schiff bases.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic and Thermal Characterization and Antioxidant Activities of Three Schiff Bases Derived from Aminophenol

Yekhlef¹,

Benghanem²,

Foudia³

et al. 2023

IJHT

View full text Add to dashboard Cite

show abstract

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

Abu‐Dief,

El‐Khatib,

El‐Dabea

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

New Cu (II), VO (II), Ag(I), and Pd (II)‐[BIP = 4,6‐dimethyl‐N‐(octahydro‐2H‐benzimidazol‐2‐ylidene)pyrimidin‐2‐amine] chelates have been synthesized by the reaction of BIP ligand resulting from the condensation of benzimidazole guanidine as well as acetylacetone with tested metal salts. The suggested structures of prepared compounds have been investigated spectroscopically through (FT‐IR, NMR, Mass spectra, and UV–Vis spectra), CHN analyses, conductivity, pH stability as well asmagnetic moment measurements. TGA studies have been also studied to govern the thermal behavior, stability, and decomposition of the metal chelates. Structural study of the tested chelates exposed their chemical transformation of ligand by chelation with the studied metals. The studies predicted a hexa‐coordinated geometry for the Cu and VO chelates, whereas tetra‐coordinated for the Ag and Pd chelates. DFT/B3LYP theoretical method was applied to obtain optimized geometry, molecular electrostatic potential (MEP) surface, and HOMO‐LUMO analysis for tested compounds. For estimation in the in vitro study, all the tested compounds have been screened for their biochemical features, including antioxidant, antimicrobial performances, and cytotoxicity. The antioxidant performance of prepared molecules has been studied by DPPH study and all the tested chelates displayed close antioxidant performance against the standard drugs. The cytotoxic analysis of tested compounds has been estimated against various cancer cell lines: (Hep‐G2, HCT‐116, and MCF‐7) using MTT analysis as well as calculated the cell viability for the corresponding human cell. The DNA binding capability for the tested compounds has been evaluated through absorption spectroscopic, viscosity estimation, as well as gel electrophoresis. The outcomes displayed a good binding tendency through the binding constant from 1.01 × 104 to 1.99 × 104 M−1 in the order BIPCu> BIPVO > BIPPd > BIPAg, respectively. Finally, docking simulation results indicated that the complexes were located in the intercalation site of DNA and confirmed experimental findings.

show abstract

New Ruthenium-p-Cymene Complexes Containing o-Vanillin and 4-Benzoxybenzaldehyde Schiff Base Ligands; Synthesis, Characterization and Catalytic Activity in the Transfer Hydrogenation of Ketones

Sarıdağ

Buldurun²

2023

Catal Lett

View full text Add to dashboard Cite

DNA interaction studies of Cu(II), Co(II), and Ni(II) chelates derived from schiff base ligand

Cited by 9 publications

References 41 publications

Synthesis, Spectroscopic and Thermal Characterization and Antioxidant Activities of Three Schiff Bases Derived from Aminophenol

Synthesis, Spectroscopic and Thermal Characterization and Antioxidant Activities of Three Schiff Bases Derived from Aminophenol

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

New Ruthenium-p-Cymene Complexes Containing o-Vanillin and 4-Benzoxybenzaldehyde Schiff Base Ligands; Synthesis, Characterization and Catalytic Activity in the Transfer Hydrogenation of Ketones

Contact Info

Product

Resources

About