DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+

Gao, Feng; Chao, Hui; Zhou, Feng; Yuan, Yali; Peng, Bin; Ji, Liang‐Nian

doi:10.1016/j.jinorgbio.2006.04.008

Cited by 259 publications

(94 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results suggest that the more polar the solvent is, the smaller relative intensities are observed. This phenomenon has also been found with the [Ru II (dppz)] complexes under similar conditions [13]. Fig.…”

supporting

confidence: 81%

See 1 more Smart Citation

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)

Tan¹,

Wang²,

Chao³

et al. 2008

Helvetica Chimica Acta

Self Cite

View full text Add to dashboard Cite

A novel polypyridine ligand, dipyrido[3,2-a:2',3'-c]phenazine-11-carboxylic acid methyl ester (¼ dppz-11-CO 2 Me), and its ruthenium(II) complex, [Ru(bpy) 2 (dppz-11-CO 2 Me)] 2þ (1), were synthesized and characterized. The binding properties of this complex to calf-thymus DNA (CT-DNA) were investigated by different spectrophotometric methods and viscosity measurements. The results suggest that the complex binds to DNA in an intercalative mode and serves as a molecular light switch for DNA. When irradiated at 365 nm, the complex 1 promoted the photocleavage of plasmid pBR-322 DNA.Introduction. -During the past decades, a number of transition-metal complexes have been utilized in the design and development of synthetic restriction enzymes, chemotherapeutic drugs, DNA footprinting agents, and stereoselective probes of nucleic acid structures [1 -10]. Binding studies of small molecules to DNA are very important in the development of DNA molecular probes and new therapeutic reagents [11 -13]. (Polypyridine)ruthenium(II) complexes can bind to DNA in a noncovalentinteraction fashion such as electrostatic binding, groove binding [14], intercalative binding, and partial intercalative binding [15]. Many useful applications of these complexes require that the complexes bind to DNA through an intercalative mode. Therefore, much work has been done on modifying the intercalative ligand. Of these, Ru II complexes containing the ligand dppz (¼ dipyrido[3,2-a : 2',3'-c]phenazine) have emerged as the most promising metal-based molecular probes of DNA [16 -18].[Ru(bpy) 2 (dppz)] 2þ (bpy ¼ bipyridine) and [Ru(phen) 2 (dppz)] 2þ (phen ¼ 1,10-phenanthroline) show no photoluminescence in aqueous solution at room temperature but luminesce brightly upon binding intercalatively with the dppz ligand between adjacent DNA base pairs, displaying the characteristic of molecular light switches. Numerous other structural analogues with different shapes and electronic properties based on the [Ru(phen) 3 ] 2þ prototype have been synthesized and investigated [19 -25]. However, the background luminescence of the free complexes in aqueous solution and their relatively weak binding constants represent limiting factors for their application as nonradioactive nucleic acid probes.

show abstract

supporting

confidence: 81%

“…2þ , and all evidence points to H-bonding and/or excited-state H-atom transfer to the phenazine N-atoms as the mechanism of deactivation of the complexes excited state [13] [17] [27 -30]. Accordingly, a similar mechanism may be envisioned in our case.…”

Section: (Dppz)]supporting

confidence: 60%

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)

Tan¹,

Wang²,

Chao³

et al. 2008

Helvetica Chimica Acta

Self Cite

View full text Add to dashboard Cite

show abstract

“…The binding ability of the synthesized oxovanadium(IV) complexes [(L 1 )VO]Á 4H 2 O (1) and [(L 2 )VO]Á 3H 2 O (9) with HS-DNA was investigated by measuring the spectral changes of their electronic spectra during the interaction with DNA. Complex binding with DNA through intercalation usually results in hypochromism and bathochromism, due to intercalative mode involving a strong stacking interaction between an aromatic chromophore of the bound ligand and the base pairs of DNA [91,92]. Therefore, to obtain the evidence for the binding mode of compounds to DNA, spectroscopic titrations of compound solutions with DNA have been performed.…”

Section: Electronic Spectral Studiesmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

View full text Add to dashboard Cite

Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

show abstract

“…Throughout the years, a number of fluorimetric methods for the determination of nucleic acids have been developed with ethidium bromide, [40][41][42] lanthanide cations, [43][44][45] ruthenium complexes, [46][47][48] and asymmetric cyanine dyes as fluorescence probes. [49][50][51] Despite the prominence of fullerenes in bionanotechnology, the exploration of their fluorescent properties in solution remains still at a very early age.…”

Section: Introductionmentioning

confidence: 99%

Binding fullerenol C60(OH)24 to dsDNA

Pinteală¹,

Dascalu²,

Ungurenasu³

2009

IJN

View full text Add to dashboard Cite

Abstract:The first C 60 (OH) 24 -DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C 60 (OH) 24 is in proportion to the concentration of DNA in the range of 1 × 10 -9 to 8 × 10 -5 molL -1 and the detection limit was 1.3 ng mL -1 . Fullerenol C 60 (OH) 24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.

show abstract

DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+

Cited by 259 publications

References 47 publications

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Binding fullerenol C60(OH)24 to dsDNA

Contact Info

Product

Resources

About

DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+

Cited by 259 publications

References 47 publications

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN1,κN1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN4,κN5)ruthenium(2+) ([Ru(bpy)2(dppz‐11‐CO2Me)]2+)

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN1,κN1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN4,κN5)ruthenium(2+) ([Ru(bpy)2(dppz‐11‐CO2Me)]2+)

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Binding fullerenol C60(OH)24 to dsDNA

Contact Info

Product

Resources

About

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)

DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′‐bipyridine‐κN¹,κN^1′)(methyl dipyrido[3,2‐a : 2′,3′‐c]phenazine‐11‐carboxylate‐κN⁴,κN⁵)ruthenium(2+) ([Ru(bpy)₂(dppz‐11‐CO₂Me)]²⁺)