2009
DOI: 10.3109/10409230903501819
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DNA interstrand crosslink repair in mammalian cells: step by step

Abstract: Interstrand DNA crosslinks (ICLs) are formed by natural products of metabolism and by chemotherapeutic reagents. Work in E. coli identified a two cycle repair scheme involving incisions on one strand on either side of the ICL (unhooking) producing a gapped intermediate with the incised oligonucleotide attached to the intact strand. The gap is filled by recombinational repair or lesion bypass synthesis. The remaining monoadduct is then removed by Nucleotide Excision Repair (NER). Despite considerable effort, ou… Show more

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Cited by 163 publications
(175 citation statements)
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References 277 publications
(368 reference statements)
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“…HR also plays a critical role in the repair of daughter strand gaps (DSGs) that arise as a result of replication fork stalling and facilitates replication fork recovery (4,(7)(8)(9). Furthermore, in collaboration with nucleotide excision repair and translesion synthesis, HR is involved in the repair of DNA interstrand cross-links (ICLs) (10,11). Thus, HR is important for the maintenance of genome integrity, and its dysfunction can lead to various genetic disorders and cancer (12)(13)(14).…”
mentioning
confidence: 99%
“…HR also plays a critical role in the repair of daughter strand gaps (DSGs) that arise as a result of replication fork stalling and facilitates replication fork recovery (4,(7)(8)(9). Furthermore, in collaboration with nucleotide excision repair and translesion synthesis, HR is involved in the repair of DNA interstrand cross-links (ICLs) (10,11). Thus, HR is important for the maintenance of genome integrity, and its dysfunction can lead to various genetic disorders and cancer (12)(13)(14).…”
mentioning
confidence: 99%
“…Repair of bulky lesions often is associated with homologous recombination (HR), as suggested for the removal of DNA interstrand crosslinks (5), likely accounting for subsequent genome instability. Because there is no direct generation of double-strand breaks (DSBs), the underlying mechanism of recombination, including initiation, is generally not well understood.…”
mentioning
confidence: 99%
“…In the case of DNA replication, lesions on template strands are tolerated by translesion DNA synthesis (TLS) polymerases that provide error-prone or error-free bypass of the blocking lesions (15,16). TLS enables NER to process a variety of bulky lesions, including drug-induced DNA crosslinks (5,17). With increases in dose, TLS could take on an even more important role in repair, because there would be increased likelihood of lesions in the template strand.…”
mentioning
confidence: 99%
“…There has been reported when the DNA replication fork is encountered or during its repair, DNA interstrand crosslinks can be formed to be DSBs through the repair system of cells [24]. The appearance of phosphorylated γ-H2AX foci is considered to be a marker for recruiting DSBs repair proteins.…”
Section: Discussionmentioning
confidence: 99%