DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs

Abstract

This is the first study in BMI-discordant MZ twin pairs reporting genome-wide DNA methylation and expression profiles in SAT. We found a number of novel genes and pathways whose methylation and expression patterns differ within the twin pairs, suggesting that the pathological adaptation of SAT to obesity is, at least in part, epigenetically regulated.

Comparative transcriptomic analyses of two bighead carp ( Hypophthalmichthys nobilis ) groups with different growth rates

“…Together with the skeletal muscle and adipose tissue, the liver is crucial in the regulation of lipid metabolism. At the same time, epigenetic alterations in monozygotic twin pairs were also found, which means that methylation may also play an important role in growth regulation (Pietilainen et al, 2016).…”

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

“…The second replication sample included 69 Finnish twins (mean age 31 years, 585 mean BMI 27.5, 44.9% male; see S6 Table), who were recruited as a part of the 586 Finnish twin cohort. The Finnish twin cohort has been previously described in 587 detail (72,73). The sample included 34 full MZ twin pairs and 21 current smokers.…”

Sleep quality and body mass index: a co‐twin study

“…For those analyses we used only complete pairs that were discordant for the outcome variable. Hence, we selected pairs discordant for BMI, using a cut-off point of 3 kg m À2 difference in BMI between co-twins, according to a common criterion in discordant twin research (Bogl et al, 2016;Pietil€ ainen et al, 2016). Using this criterion, we identified 430 [dizygotic (DZ): 316; monozygotic (MZ): 114] discordant pairs (Fig.…”