DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis

Zhang, Meichun; Wu, Jing; Wu, Zhong; Zhao, Ziwen; He, Weiguo

doi:10.1016/j.omto.2021.09.006

Cited by 17 publications

(18 citation statements)

References 63 publications

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“…Previous study has shown that DNA methylation of TMEM130 promotes cell migration in breast cancer (35). DIO3OS DNA methylation drives non-small cell lung cancer progression (36). ANGPTL4 DNA methylation promotes colorectal cancer metastasis by activating the ERK pathway (37).…”

Section: Discussionmentioning

confidence: 98%

Comprehensive analysis of the collagen family members as prognostic markers in clear cell renal cell carcinoma

Guo¹,

An²,

Huang³

et al. 2022

Transl Cancer Res TCR

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Background: Clear cell renal cell carcinoma (ccRCC) is one of the common malignant tumors worldwide.There is still a lack of effective diagnostic and therapeutic targets for the recurrence and metastasis of ccRCC. In this study, we sought to identify effective diagnostic and therapeutic targets for ccRCC recurrence and metastasis.Methods: Gene Expression Omnibus (GEO) dataset was used to obtain differentially expressed genes (DEGs) between primary and metastasis ccRCC. We used The Cancer Genome Atlas (TCGA), GeneMANIA, cBioPortal, MethSurv, and TIMER to analyze the expression differences, mutation status, prognostic value, molecular function, and immune infiltration of hub genes in renal cell carcinoma (RCC).Results: We obtained a total of 35 different gene lists. Six collagen family members were identified as hub genes. The expression level of collagen family members was closely related to ccRCC. Moreover, differences in the expression levels of collagen family members were closely related to the stage and prognosis of ccRCC.Members of the collagen family were responsible for more than 15% of the genetic alterations in ccRCC and are involved in multiple signaling pathways. The expression level of collagen family members was closely related to the infiltration of tumor-associated immune cells. Univariate and multivariate Cox regression identified the prognosis-related genes: COL5A1.Conclusions: Our study implied that members of the collagen family may serve as a biomarker for ccRCC metastasis and prognosis.

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Section: Discussionmentioning

confidence: 98%

Comprehensive analysis of the collagen family members as prognostic markers in clear cell renal cell carcinoma

Guo¹,

An²,

Huang³

et al. 2022

Transl Cancer Res TCR

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“…Together, all these observations suggest that HNRNPK might perform its complex functions in multiple ways in different cancer contexts. DNA-methylation-induced silencing of DIO3OS has been demonstrated to drive non-small cell lung cancer progression via activating HNRNPK-MYC-CDC25A axis 41 . We demonstrated that HNRNPK functions as an oncogene in lung cancer by binding MYC mRNAs to promote the cancer development and progression.…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

et al. 2023

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RNA-binding proteins (RBPs) are key players of gene expression and perturbations of RBP-RNA regulatory network have been observed in various cancer types. Here, we propose a computational method, RBPreg, to identify the RBP regulators by integration of single cell RNA-Seq (N = 233,591) and RBP binding data. Pan-cancer analyses suggest that RBP regulators exhibit cancer and cell specificity and perturbations of RBP regulatory network are involved in cancer hallmark-related functions. We prioritize an oncogenic RBP-HNRNPK, which is highly expressed in tumors and associated with poor prognosis of patients. Functional assays performed in cancer cells reveal that HNRNPK promotes cancer cell proliferation, migration, and invasion in vitro and in vivo. Mechanistic investigations further demonstrate that HNRNPK promotes tumorigenesis and progression by directly binding to MYC and perturbed the MYC targets pathway in lung cancer. Our results provide a valuable resource for characterizing RBP regulatory networks in cancer, yielding potential biomarkers for precision medicine.

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“…Although emerging studies have revealed the important functions of HNRNPK and MYC in cancer, limited evidence were supported in lung cancer. DNA-methylation-induced silencing of DIO3OS has been demonstrated to drive non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis 37 . We demonstrated that HNRNPK functions as an oncogene in lung cancer by binding MYC to promote the cancer development and progression.…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

Zhou

Jie

et al. 2022

Preprint

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RNA-binding proteins (RBPs) are key players of gene expression and perturbation of RBP-RNA regulatory network has been observed in various cancer types. Here, we propose a computational method, RBPreg, to identify the RBP regulators by integration of single cell RNA-Seq (N = 233,591) and RBP binding data. Pan-cancer analyses suggest that RBP regulators exhibit cancer and cell specificity and perturbation of RBP regulatory network is involved in cancer hallmark-related functions. We prioritize an oncogenic RBP-HNRNPK, which is highly expressed in tumors and associated with poor prognosis of patients. Functional assays performed in cancer cells reveal that HNRNPK promotes cancer cell proliferation, migration, and invasion in vitro and in vivo. Mechanistic investigations further demonstrate that HNRNPK promotes tumorigenesis and progression by directly binding to MYC and perturbed the MYC targets pathway in lung cancer. Our results provide a valuable resource for characterizing RBP regulatory networks in cancer, yielding potential biomarkers for precision medicine.

show abstract

DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis

Cited by 17 publications

References 63 publications

Comprehensive analysis of the collagen family members as prognostic markers in clear cell renal cell carcinoma

Comprehensive analysis of the collagen family members as prognostic markers in clear cell renal cell carcinoma

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

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