DNA methylation is regulated by both the stability and topology of G-quadruplex

Matsumoto, Saki; Sugimoto, Naoki

doi:10.1039/d2cc04383a

Cited by 3 publications

(1 citation statement)

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“…DNA methylation involves the covalent attachment of a methyl group to the 5th carbon position of cytosine within CpG dinucleotides in the genome and is catalyzed by DNA methyltransferases [ 13 ]. Extensive research has demonstrated that DNA methylation can induce changes in chromatin structure, DNA conformation, DNA stability, and interactions between DNA and proteins, thereby regulating gene expression [ 14 , 15 ]. DNA methylation is among the earliest discovered and most thoroughly studied epigenetic regulatory mechanisms.…”

Section: Basic Mechanism Of Dna Methylationmentioning

confidence: 99%

An Epigenetic Manifestation of Alzheimer's Disease: DNA Methylation

Feng,

Zheng,

Cai

et al. 2024

Actas Esp Psiquiatr

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Alzheimer's disease (AD), the most common form of dementia, has a complex pathogenesis. The number of AD patients has increased in recent years due to population aging, while a trend toward a younger age of onset has arisen, imposing a substantial burden on society and families, and garnering extensive attention. DNA methylation has recently been revealed to play an important role in AD onset and progression. DNA methylation is a critical mechanism regulating gene expression, and alterations in this mechanism dysregulate gene expression and disrupt important pathways, including oxidative stress responses, inflammatory reactions, and protein degradation processes, eventually resulting in disease. Studies have revealed widespread changes in AD patients' DNA methylation in the peripheral blood and brain tissues, affecting multiple signaling pathways and severely impacting neuronal cell and synaptic functions. This review summarizes the role of DNA methylation in the pathogenesis of AD, aiming to provide a theoretical basis for its early prevention and treatment.

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Section: Basic Mechanism Of Dna Methylationmentioning

confidence: 99%

An Epigenetic Manifestation of Alzheimer's Disease: DNA Methylation

Feng,

Zheng,

Cai

et al. 2024

Actas Esp Psiquiatr

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Inverted strand polarity yields thermodynamically stable G-quadruplexes and prevents duplex formation within extended DNA

Chilton,

Roach,

Edwards

et al. 2024

Chem. Sci.

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Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects

Han¹,

Wen²

2023

World J Gastrointest Oncol

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Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.

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DNA methylation is regulated by both the stability and topology of G-quadruplex

Abstract: Since DNA methylation alters chromatin state and regulates gene expression, elucidating the regulatory mechanisms of DNA methylation in response to environmental changes in the cell is crucial and urgent in...

Cited by 3 publications

References 31 publications

An Epigenetic Manifestation of Alzheimer's Disease: DNA Methylation

An Epigenetic Manifestation of Alzheimer's Disease: DNA Methylation

Inverted strand polarity yields thermodynamically stable G-quadruplexes and prevents duplex formation within extended DNA

Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects

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