DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health

Miyake, Kunio; Miyashita, Chihiro; Ikeda‐Araki, Atsuko; Miura, Ryuichi; Itoh, Shinji; Yamazaki, Keiko; Kobayashi, Sumitaka; Masuda, Hideyuki; Ooka, Tadao; Yamagata, Zentaro; Kishi, Reiko

doi:10.1186/s13148-021-01063-z

Cited by 17 publications

(12 citation statements)

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“…The DNA methylation levels were examined via next-generation sequencing t in a region of each gene. We examined whether the changes in DNA methylation mediate the association between prenatal smoking and ADHD symptoms, finding that DNA methylation of the GF11 region mediated 48.4% of the total association between maternal active smoking during pregnancy and ADHD symptoms [ 82 ].…”

Section: Resultsmentioning

confidence: 99%

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Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Kishi

Ikeda‐Araki

Miyashita

et al. 2021

Environ Health Prev Med

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Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco. Methods The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures. Results The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies. Conclusions Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future.

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Section: Resultsmentioning

confidence: 99%

“…In addition, the results of the Hokkaido Study also suggest that certain chemicals alter DNA methylation in humans [ 79 – 82 , 102 ]. Exposure to environmental chemicals during pregnancy causes child epigenome changes at specific sites in a wide range of functional genes at birth.…”

Section: Discussionmentioning

confidence: 99%

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Kishi

Ikeda‐Araki

Miyashita

et al. 2021

Environ Health Prev Med

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“…Prenatal toxic exposure affects the fetus and is one of the main determinants of early childhood development (Fernald et al, 2017; World Health Organization, UNICEF, World Bank Group, 2018). The effect of exposure may continue throughout life by epigenetics (Miyake et al, 2021). It was shown that maternal prenatal smoking influenced reading and math test scores and had a prominently negative impact on cognitive development in the long term (Anthopolos et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Strengths and difficulties in children with specific learning disabilities

Ayar

Yalçin

Artan

et al. 2021

Child

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Background: The study aims to investigate the social, emotional, and behavioral challenges in children with a specific learning disability (SLD) and to identify the factors that accompany these problems by screening with the Strengths and Difficulties Questionnaire (SDQ). Methods:The descriptive study was conducted on 278 children with SLD. Strengths and difficulties in children were evaluated by the SDQ applied to their mothers. The percentage of cases above the cut-off limits of the SDQ was calculated. Chi-square test and multiple logistic regression analysis were used for analysis. Results:The mean (SD) total SDQ score was 15.8 (6.5). The percentage of scores of abnormal total difficulties in SLD was 47.8%. Multivariate analysis revealed that cases exposed to antenatal smoking had higher odds ratio of abnormal emotional symptoms and abnormal total difficulties; cases with poor familial income and the presence of a history of antenatal smoking exposure showed considerably higher odds ratio of conduct problems; cases with younger age at the diagnosis of SLD, dyscalculia, extreme duration of preschool screen time (≥4 h), and history of hospitalization had significantly higher odds ratio for hyperactivity-inattention problems; and cases having shorter breastfeeding duration had higher odds ratio of peer problems compared to counterparts. Conclusion:Children with SLD have a high score on the SDQ. Practitioners could especially give guidance and support to families with financial problems and those having a child with an early age at diagnosis, exposure to antenatal smoking, short breastfeeding period, early age of the first screen use, and long screen exposure duration during the preschool period.

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“…During pregnancy, nutritional changes take place to supply the demands of both the mother and the foetus, and they are important for the normal development of the foetus [ 2 ]. Besides the mother’s diet, the foetus is susceptible to damage by maternal diseases, such as type 2 diabetes (T2D), obesity [ 3 , 4 , 5 ], or smoking [ 6 , 7 ], and the consumption of alcohol [ 8 , 9 ]. Under these conditions, free radicals (FR) are overproduced and accumulate in cells.…”

Section: Introductionmentioning

confidence: 99%

Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

Díaz-García

Vilchis-Gil

García-Roca

et al. 2022

Life

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During pregnancy, appropriate nutritional support is necessary for the development of the foetus. Maternal nutrition might protect the foetus from toxic agents such as free radicals due to its antioxidant content. In this study, 90 mothers and their children were recruited. DNA damage mediated by oxidative stress (OS) was determined by the levels of 8-hidroxy-2′-deoxyguanosine (8-OHdG) in the plasma of women and umbilical cord blood. The mothers and newborns were categorised into tertiles according to their 8-OHdG levels for further comparison. No relevant clinical differences were observed in each group. A strong correlation was observed in the mother–newborn binomial for 8-OHdG levels (Rho = 0.694, p < 0.001). In the binomial, a lower level of 8-OHdG was associated with higher consumption of calories, carbohydrates, lipids, and vitamin A (p < 0.05). In addition, the levels of 8-OHdG were only significantly lower in newborns from mothers with a higher consumption of vitamin A and E (p < 0.01). These findings were confirmed by a significant negative correlation between the 8-OHdG levels of newborns and the maternal consumption of vitamins A and E, but not C (Rho = −0.445 (p < 0.001), −0.281 (p = 0.007), and −0.120 (p = 0.257), respectively). Multiple regression analysis showed that the 8-OHdG levels in mothers and newborns inversely correlated with vitamin A (β = −1.26 (p = 0.016) and −2.17 (p < 0.001), respectively) and pregestational body mass index (β = −1.04 (p = 0.007) and −0.977 (p = 0.008), respectively). In conclusion, maternal consumption of vitamins A and E, but not C, might protect newborns from DNA damage mediated by OS.

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DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health

Cited by 17 publications

References 58 publications

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Strengths and difficulties in children with specific learning disabilities

Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

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