DNA methylation of ITGB2 contributes to allopurinol hypersensitivity

Liu, Yu; Wang, Chuang‐Wei; Chen, Chun‐Bing; Yu, Kuang‐Hui; Wu, Yeong‐Jian Jan; Choon, Siew Eng; Chang, Wen Han; Yang, Feng; Luo, Xiaoqun; Chung, Wen‐Hung; Zhao, Ming; Lu, Qianjin

doi:10.1016/j.clim.2023.109250

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…In addition, serum TARC level was identified as a potential biomarker for DRESS severity and prognosis ( Komatsu-Fujii et al, 2018 ). Moreover, epigenetic association has been found in SCARs patients (such as ITGB2 methylation associated with allopurinol-induced SCARs) ( Liu et al, 2023 ). Recently, the high-throughput technologies including whole genome sequencing (WGS) and whole exome sequencing (WES) offer us rapid method to screen the genetic variants ( Wang et al, 2022a ).…”

Section: Current Trends and Future Perspectivesmentioning

confidence: 99%

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Wung¹,

Wang²,

Lai³

et al. 2023

Front. Pharmacol.

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Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare burden in every country. Increasing reports of DHRs have caught our attention to explore the genetic relationship, especially life-threatening severe cutaneous adverse drug reactions (SCARs), including acute generalized exanthematous pustulosis (AGEP), drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). In recent years, many studies have investigated the immune mechanism and genetic markers of DHRs. Besides, several studies have stated the associations between antibiotics-as well as anti-osteoporotic drugs (AOD)-induced SCARs and specific human leukocyte antigens (HLA) alleles. Strong associations between drugs and HLA alleles such as co-trimoxazole-induced DRESS and HLA-B*13:01 (Odds ratio (OR) = 45), dapsone-DRESS and HLA-B*13:01 (OR = 122.1), vancomycin-DRESS and HLA-A*32:01 (OR = 403), clindamycin-DHRs and HLA-B*15:27 (OR = 55.6), and strontium ranelate (SR)-SJS/TEN and HLA-A*33:03 (OR = 25.97) are listed. We summarized the immune mechanism of SCARs, update the latest knowledge of pharmacogenomics of antibiotics- and AOD-induced SCARs, and indicate the potential clinical use of these genetic markers for SCARs prevention in this mini review article.

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Section: Current Trends and Future Perspectivesmentioning

confidence: 99%