2014
DOI: 10.1038/srep04302
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DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related

Abstract: The human gut is a reservoir for antibiotic resistance genes. In this report, we used a DNA microarray chip covering 369 resistance types to investigate the relationship between antibiotic resistance-gene diversity and human age. Metagenomic DNA from fecal samples from 124 healthy volunteers of four different age groups (pre-school-aged children (CH), school-aged children (SC), high school students (HSS) and adults (AD)) were hybridized to the microarray chip. The results showed that 80 different gene types we… Show more

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Cited by 57 publications
(55 citation statements)
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“…Another study demonstrated the differences between the age groups in susceptibility patterns among E. coli urinary tract isolates for all tested antibiotics except co-trimoxazole (25) . A microarray-based study showed that the antibiotic resistance gene diversity is age-related and that these genes accumulate in the members of human gut microflora starting from infancy, and their interactions become gradually more complex with age (26) . To the best of our knowledge, the differences in the Acinetobacter susceptibility to different antimicrobial agents between different age groups have not been reported before.…”
Section: Discussionmentioning
confidence: 99%
“…Another study demonstrated the differences between the age groups in susceptibility patterns among E. coli urinary tract isolates for all tested antibiotics except co-trimoxazole (25) . A microarray-based study showed that the antibiotic resistance gene diversity is age-related and that these genes accumulate in the members of human gut microflora starting from infancy, and their interactions become gradually more complex with age (26) . To the best of our knowledge, the differences in the Acinetobacter susceptibility to different antimicrobial agents between different age groups have not been reported before.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, twins display remarkably greater resistome similarity to each other than to unrelated infants or their mothers, suggesting that vertical transmission does not play a crucial role in its establishment. Moreover, the resistome expands over time, as the number of ARGs within the human microbiome positively correlate with age [106]. …”
Section: Generation Of Antibiotic Resistance: the Driving Forcesmentioning
confidence: 99%
“…Sjölund et al (2003) reported that resistant enterococci harboring the ermB gene were isolated immediately after and up to 3 years following antibiotic treatment. Reports have also observed that older individuals have higher levels of ARGs (Lu et al 2014), which may be due to increased exposure to antimicrobials. Our observation suggests that such accumulation can also be due to exposure to an environmental toxicant such as TCDD.…”
Section: Abundance Of Args 30 Days Post Cessation Of Dosingmentioning
confidence: 99%