DNA Mismatch Repair Deficiency in Colorectal Adenocarcinoma and its Association with Clinicopathological Features

Zhi, Wenxue; Ying, Jianming; Zhang, Yefan; Li, Wenbin; Zhao, Hong; Lü, Ning; Shi, Susheng

doi:10.4172/2161-0681.1000220

Cited by 1 publication

(2 citation statements)

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“…MMR protein loss is more commonly seen in right sided tumours compared to left sided and rectal tumours as was evident in this series as well. This is similar to studies from other parts of the world, [24][25][26]29 however, Ravikanth et al 30 reported MSI-H status to be present most commonly in rectal cancer (66%).…”

Section: Discussionsupporting

confidence: 87%

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Pattern of mismatch repair protein loss and its clinicopathological correlation in colorectal cancer in North India

et al. 2018

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Background: To determine the mismatch repair (MMR) protein loss in colorectal cancer (CRC) in north Indian patients and its clinicopathological correlation. Methods: A prospective study on patients with colorectal cancer from a tertiary level hospital conducted between May 2014 and June 2015. MMR protein loss was determined using immunohistochemistry for MLH1, MSH2, PMS2 and MSH6. Results: 52 patients (38 male and 14 females) of CRC, with median age of 52.5 years who underwent resection form the study group. 18 (35%) patients were < 50 years of age. Family history of malignancy was present in 3 (6 %) patients. A total of 15 (29%) patients had loss of MMR protein of which 7 (46%) were < 50 years. Most common MMR loss was combined loss of MSH2 + MSH6 [6 (11.5%)] followed by isolated loss of PMS2 [5 (9.6%)]. MMR protein loss was more frequent in patients with right side colon cancer [12 (42%)] compared to left [3 (13%)] (p = 0.033). MMR protein loss was seen in 11 (34%) out of 32 patients fulfilling the revised Bethesda criteria compared to 4 (20%) out of 20 patients who did not fulfil the criteria (p = 0.352). Conclusion: This study demonstrates high frequency of MMR protein loss in colorectal cancer in north Indian patients which was more common in right colon cancer. Many patients having MMR protein loss do not satisfy the revised Bethesda criteria and would have been missed if selective testing was done. Further research and larger studies are required to validate these findings and develop India specific clinical criteria.

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Section: Discussionsupporting

confidence: 87%

“…[22][23][24] Wenxue Zhi et al from China reported MMR loss in 7% patients. 25 A recent study from north India by Dubey et al reported MSI-high in 22% patients. 26 Earlier, two studies from India by Pandey et al 27 and Malhotra et al 28 have reported MMR protein loss from 17.8-19.9%.…”

Section: Discussionmentioning

confidence: 95%