DNA-modified boron-doped diamond electrode as a simple electrochemical platform for detection of damage to DNA by antihypertensive amlodipine

Svítková, Jana; Švikruhová, Silvia; Vojs, Marián; Marton, Marián; Švorc, Ľubomír

doi:10.1007/s00706-016-1729-3

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Literature reports the use of several sensing materials in the determination of anti-hypertensive drugs such as methyldopa. Amongst these electrodic devices, the most used are boron doped diamond [22,23] and glassy carbon electrode (GCE) [21,22,23,24]. Albeit widely explored in analytical studies, diamond-based electrodes are unpractical due to their high cost, while GCE may not provide adequate reproducibility hence electrode surface fouling.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa

et al. 2018

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Methyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 μmol/L (Limit of Detection = 1 μmol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds.

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Section: Introductionmentioning

confidence: 99%

Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa

et al. 2018

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“…[21][22][23] Several research groups, including ours, study the electrochemical behavior and application of electrode materials in electroanalytical methods to quantify natural compounds. [24][25][26][27][28][29][30][31][32][33] To the best of our knowledge, there is only one published peer-reviewed study about determination of TUB using electrochemical procedure based on ion selective membrane method. 34 Based on the importance of this biological compound for various applications, gaining more insight in electrochemical behavior should be essential for scientist working in the field of electrochemistry.…”

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confidence: 99%

Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches

Đurđić

Stanković

Perić

et al. 2019

J. Electrochem. Soc.

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In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L −1 nitric acid, which had linear quantification ranges from 4 × 10 −6 to 1 × 10 −4 mol L −1 (LOD = 3.07 × 10 −6 mol L −1 ) and 4 × 10 −6 to 9 × 10 −5 mol L −1 (LOD = 2.45 × 10 −6 mol L −1 and 5.28 × 10 −7 mol L −1 , depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.

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