DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Han, Yaopin; Wu, Yixing; He, Binfeng; Wu, Di; Hua, Jianlan; Qian, Hang; Zhang, Jing

doi:10.1039/d3na00547j

Nanoscale Adv.

2023

DOI: 10.1039/d3na00547j

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DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Yaopin Han,

Yixing Wu,

Binfeng He

et al.

Abstract: The pathogenesis and development of chronic obstructive pulmonary disease (COPD) is significantly related to cellular senescence. Strategies to eliminate senescent cells have been confirmed to benefit several senescence-related diseases. However,...

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2024

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Drug Delivery Strategies for Age-Related Diseases

Yoshihara,

Horiguchi

2024

IJMS

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Drug delivery systems (DDSs) enable the controlled release of drugs in the body. DDSs have attracted increasing attention for the treatment of various disorders, including cancer, inflammatory diseases, and age-related diseases. With recent advancements in our understanding of the molecular mechanisms of aging, new target molecules and drug delivery carriers for age-related diseases have been reported. In this review, we will summarize the recent research on DDSs for age-related diseases and identify DDS strategies in the treatment of age-related diseases.

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Drug Delivery Strategies for Age-Related Diseases

Yoshihara,

Horiguchi

2024

IJMS

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show abstract

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DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Abstract: The pathogenesis and development of chronic obstructive pulmonary disease (COPD) is significantly related to cellular senescence. Strategies to eliminate senescent cells have been confirmed to benefit several senescence-related diseases. However,...

Cited by 1 publication

References 56 publications

Drug Delivery Strategies for Age-Related Diseases

Drug Delivery Strategies for Age-Related Diseases

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