DNA nanostructures: a shift from assembly to applications

Lanier, Laura; Bermudez, Harry

doi:10.1016/j.coche.2015.01.001

Cited by 23 publications

(11 citation statements)

References 43 publications

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“…DNA self-assembling nanostructure (Lanier and Bermudez, 2015; Kim et al, 2016; Xia et al, 2016), especially DNA origami, has been considered as the most promising candidates as a drug delivery carrier for cancer therapy (Zhao et al, 2012; Ouyang et al, 2013; Zhu et al, 2013; Zhang et al, 2014; Jiang et al, 2015; Zhuang et al, 2016). DNA origami were prepared through the self-assembly of a long single stranded M13mp18 phage DNA and hundreds of complementary short DNA staples, which endows the structure with high levels of structural programmability, obvious biocompatibility, and easiness to be modified with functional moieties.…”

Section: Dna Origami For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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Cancer stem cells (CSCs) have been identified in almost all cancers and give rise to metastases and can also act as a reservoir of cancer cells that may cause a relapse after surgery, radiation, or chemotherapy. Thus they are obvious targets in therapeutic approaches and also a great challenge in cancer treatment. The threat presented by CSCs lies in their unlimited proliferative ability and multidrug resistance. These findings have necessitated an effective novel strategy to target CSCs for cancer treatment. Nanomaterials are on the route to providing novel methods in cancer therapies. Although, there have been a large number of excellent work in the field of targeted cancer therapy, it remains an open question how nanomaterials can meet future demands for targeting and eradicating of CSCs. In this review, we summarized recent and highlighted future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials.

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Section: Dna Origami For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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“…Crosslinkers that degrade or hydrolyze in response to different endogenous stimuli such as acidic pH (e.g. 2,2-dimethacroyloxy-1-ethoxypropane [24,74], HEMA-lactate-Dextran [75–78], poly(l-lactic acid)[79]), redox potential (e.g. bis(2-methacryloyloxyethyl) disulfide [80] and disulfide-containing crosslinker N,N’- bis(acryloyl) cystamine [40]) or enzymes (e.g.…”

Section: Thermoresponsive Nanomaterialsmentioning

confidence: 99%

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.

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“…DNA is a versatile material for building nanoscale structures since it can be used to construct large assemblies that form as a result of hybridization between strands. [1][2][3][4][5] These assemblies can form a large array of different shapes and come together in a passive manner through base pairing interactions. An important class of functional nucleic acids are aptamers.…”

Section: Introductionmentioning

confidence: 99%