Mater. Horiz.
 2025
DOI: 10.1039/d4mh01158a
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DNA nanotechnology-based strategies for minimising hybridisation-dependent off-target effects in oligonucleotide therapies

Xiaoyu Li,
Huanhuan Hu,
Hailong Wang
et al.

Abstract: Targeted therapy has emerged as a transformative breakthrough in modern medicine. Oligonucleotide drugs, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have made significant advancements in targeted therapy....

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