DNA of diverse adenoviruses detected in Cameroonian rodent and shrew species

Diffo, Joseph Le Doux; Ndze, Valentine Ngum; Ntumvi, Nkom F; Takuo, Jean-Michel; Mouiche, Moctar M M; Tamoufé, Ubald; Nwobegahay, Julius; LeBreton, Matthew; Gillis, Amethyst; Schneider, Bradley S.; Fair, Joseph M; Monagin, Corina; McIver, David J; Joly, Damien O.; Wolfe, Nathan; Rubin, Edward M.; Lange, Christian E.

doi:10.1007/s00705-019-04323-9

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…The presence of AdV genomes in rodents has been previously reported in other studies [66][67][68][69]. In particular, two AdV types have already been isolated from house mice (Mus musculus): MAdV-1 and MAdV-2, with the latter being responsible for infections of the gastrointestinal tract [66].…”

Section: Discussionsupporting

confidence: 57%

Mastadenovirus Molecular Diversity in Waste and Environmental Waters from the Lisbon Metropolitan Area

et al. 2022

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In face of the absence of epidemiological data regarding the circulation of human adenoviruses (HAdV) in Portugal, this study aimed at the evaluation of their molecular diversity in waste and environmental waters in the Lisbon Metropolitan Area (LMA). Using samples collected between 2018 and 2021, the HAdV hexon protein-coding sequence was partially amplified using three nested touch-down PCR protocols. The amplification products obtained were analyzed in parallel by two approaches: molecular cloning followed by Sanger sequencing and Next-Generation Sequencing (NGS) using Illumina® sequencing. The analysis of NGS-generated data allowed the identification of a higher diversity of HAdV-A (19%), -B (1%), -C (3%), -D (24%), and -F (25%) viral types, along with murine adenovirus (MAdV-2; 30%) in the wastewater treatment plant samples. On the other hand, HAdV-A (19%), -D (32%), and -F (36%) were identified in environmental samples, and possibly MAdV-2 (14%). These results demonstrate the presence of fecal contamination in environmental waters and the assessment of the diversity of this virus provides important information regarding the distribution of HAdV in LMA, including the detection of HAdV-F41, the most frequently reported in water worldwide.

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Section: Discussionsupporting

confidence: 57%

Mastadenovirus Molecular Diversity in Waste and Environmental Waters from the Lisbon Metropolitan Area

et al. 2022

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“…An AdV, found in common squirrel, has also been fully sequenced . Novel AdVs were detected in different wild rodents in Cameroon . Moreover, AdV isolates from captive guinea pigs kept in Australia and the Czech Republic have just been reported .…”

Section: Advs In Mammals (Mastadenovirus Atadenovirus)mentioning

confidence: 99%

“…Several representatives of additional mammalian species were found to harbor AdV, including tree shrew, rabbit, and different shrew species . One of the two AdV types known to infect horses, namely equine AdV‐1, also appears to originate from micro BtAdVs (Fig.…”

Section: Advs In Mammals (Mastadenovirus Atadenovirus)mentioning

confidence: 99%

Adenoviruses across the animal kingdom: a walk in the zoo

2019

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Adenoviruses (AdVs) infect representatives of numerous species from almost every major vertebrate class, albeit their incidence shows great variability. AdVs infecting birds, reptiles, and bats are the most common and diverse, whereas only one AdV has been so far isolated both from fish and amphibians. The family Adenoviridae is divided into five genera, each corresponding to an independent evolutionary lineage that supposedly coevolved with its respective vertebrate hosts. Members of genera Mastadenovirus and Aviadenovirus seem to infect exclusively mammals and birds, respectively. The genus Ichtadenovirus includes the single known AdV from fish. The majority of AdVs in the genus Atadenovirus originated from squamate reptiles (lizards and snakes), but also certain mammalian and avian AdVs are classified within this genus. The genus Siadenovirus contains the only AdV isolated from frog, along with numerous avian AdVs. In turtles, members of a sixth AdV lineage have been discovered, pending official recognition as an independent genus. The most likely scenario for AdV evolution includes long‐term cospeciation with the hosts, as well as occasional switches between closely or, rarely, more distantly related hosts.

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“…Virus–host co-evolution and species specificity have generally been regarded as the driving factors for AdV evolution and diversity, despite the relative host ambiguity of CAdV-1 [5, 7, 24]. However, recent findings, such as evidence for human–primate zoonotic events and results from surveys in rodents and bats, indicate that matters may be more complex [1, 6, 8–12, 14–16, 23]. The results of the Jane analysis, with relatively few (9) predicted co-speciation events and an overall high total cost of 254 (the higher the influence of co-speciation the closer it would be to 0), also point towards a complex evolution of bat AdVs that involves, but not primarily depends on, co-evolution.…”

Section: Discussionmentioning

confidence: 99%

“…Identifying and studying these viruses can provide insights into what drives AdV evolution, mechanisms of pathogenicity, and general virus and host biology. The most promising hosts in which to look for AdVs in terms of characterizing evolution are certainly rodents and bats, as these two orders alone account for over 70 % of all living mammal species, and recent studies have indeed unveiled many previously unknown AdVs in these hosts [2,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bat adenoviruses suggests co-evolution and host roosting behaviour as drivers for diversity

et al. 2021

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Adenoviruses (AdVs) are diverse pathogens of humans and animals, with several dozen bat AdVs already identified. Considering that over 100 human AdVs are known, and the huge diversity of bat species, many bat AdVs likely remain undiscovered. To learn more about AdV prevalence, diversity and evolution, we sampled and tested bats in Cameroon using several PCR assays for viral and host DNA. AdV DNA was detected in 14 % of the 671 sampled animals belonging to 37 different bat species. There was a correlation between species roosting in larger groups and AdV DNA detection. The detected AdV DNA belonged to between 28 and 44 different, mostly previously unknown, mastadenovirus species. The novel isolates are phylogenetically diverse and while some cluster with known viruses, others appear to form divergent new clusters. The phylogenetic tree of novel and previously known bat AdVs does not mirror that of the various host species, but does contain structures consistent with a degree of virus–host co-evolution. Given that closely related isolates were found in different host species, it seems likely that at least some bat AdVs have jumped species barriers, probably in the more recent past; however, the tree is also consistent with such events having taken place throughout bat AdV evolution. AdV diversity was highest in bat species roosting in large groups. The study significantly increased the diversity of AdVs known to be harboured by bats, and suggests that host behaviours, such as roosting size, may be what limits some AdVs to one species rather than an inability of AdVs to infect other related hosts.

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DNA of diverse adenoviruses detected in Cameroonian rodent and shrew species

Cited by 9 publications

References 16 publications

Mastadenovirus Molecular Diversity in Waste and Environmental Waters from the Lisbon Metropolitan Area

Mastadenovirus Molecular Diversity in Waste and Environmental Waters from the Lisbon Metropolitan Area

Adenoviruses across the animal kingdom: a walk in the zoo

Evaluation of bat adenoviruses suggests co-evolution and host roosting behaviour as drivers for diversity

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